Results 281 to 290 of about 72,449 (334)

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, EarlyView.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Competitive Entry in the Market for Branded Generic Drugs

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT I analyze the determinants of lead time (the time lag between the first‐mover's product release and the competitor's market entry) and its consequences for product prices, competition, and consumers. I investigate the case for the Indian branded generic pharmaceutical sector where substantial variation in lead time is observed.
Vasudha Wattal
wiley   +1 more source

Impact of emerging packaging regulations on international trade and product safety with emphasis on plastic reuse and recycling in Europe and North America

Journal of Industrial Ecology, EarlyView.
Abstract The evolving global landscape of packaging regulations, driven by heightened public concern over single‐use packaging and plastic waste, signals a significant shift toward circular economy principles. These regulatory changes, including the United Nations Environmental Programme's endorsement of a legally binding international agreement on ...
Carinna Saldaña‐Pierard, Phuong Mai Nguyen, Frédéric Debeaufort, Olivier Vitrac, Rafael Auras   +4 more
wiley   +1 more source

Predictive Performance of Device‐Neonatal Skin Risk Assessment Scale to Evaluating Pressure Injuries Risk in the Neonates. An Observational Multicenter Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To assess the validity of a modified Neonatal Skin Risk Assessment scale (Dev‐NSARS) for neonatal pressure injuries (PIs) in the neonatal intensive care unit (NICU) and neonatal sub‐intensive care unit (NICU‐Sub) environment. Background Medical devices are the leading cause of pressure injuries (PIs) in neonates, a key cause of morbidity ...
Biagio Nicolosi, Elisa Neri, Leonardo Fioravanti, Silvia Leoncini, Claudio De Felice, Pablo Garcìa‐Molina, Alessandra Mugnaini   +6 more
wiley   +1 more source

Clinical and esthetic outcomes of screw‐retained internal‐connection veneered zirconia‐ceramic CAD‐CAM abutments in single implant reconstructions: Five‐year results of a prospective case series investigation

Journal of Prosthodontics, EarlyView.
Abstract Purpose To evaluate the long‐term clinical performance and survival, as well as the biological, esthetic, and technical complications of one‐piece, internally‐connected, screw‐retained, computer aided‐design and computer aided‐manufacturing (CAD‐CAM) veneered zirconia anterior and posterior implant‐supported single restorations fabricated on ...
Rafael del Castillo, Lourdes Gutiérrez‐Garrido, Miguel Padial‐Molina, Carlo Ercoli, Pablo Galindo‐Moreno   +4 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Acute Effects of Oral Cannabinoids on Sleep and High‐Density EEG in Insomnia: A Pilot Randomised Controlled Trial

Journal of Sleep Research, EarlyView.
ABSTRACT Cannabinoids, particularly Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD), have gained popularity as alternative sleep aids; however, their effects on sleep architecture and next‐day function remain poorly understood. Here, in a pilot trial, we examined the effects of a single oral dose containing 10 mg THC and 200 mg CBD (THC/CBD) on ...
Anastasia Suraev, Iain S. McGregor, Danielle McCartney, Nathaniel S. Marshall, Chien‐Hui Kao, Rick Wassing, Angela L. D'Rozario, Keith K. H. Wong, Brendon J. Yee, Sheila Sivam, Richard C. Kevin, Ryan Vandrey, Christopher Irwin, Christopher J. Gordon, Delwyn Bartlett, Jonathon C. Arnold, Ronald R. Grunstein, Camilla M. Hoyos   +17 more
wiley   +1 more source