Results 291 to 300 of about 72,449 (334)
New Phytologist, EarlyView.Summary Guanylate‐binding proteins (GBPs) are large GTPases that belong to the Dynamin Superfamily Protein family. In humans, GBPs are well‐characterized interferon‐induced GTPases, playing a central role in cell‐autonomous innate immunity against infections, inflammation and cancer. GBPs orthologs have been identified in plants only recently.
Lucie Fernandez‐Lochu +2 more
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Plant Biotechnology Journal, EarlyView.ABSTRACT The plant virus cowpea mosaic virus (CPMV) is being developed as a drug candidate for intratumoral immunotherapy for solid tumours. Data from preclinical studies in mice and rats as well as clinical studies in canine cancer patients demonstrate potent efficacy and an excellent safety profile.
Patrick Opdensteinen +3 more
wiley +1 more source
Cyclic GMP and Cell Movement [PDF]
Nature, 1973 THE movement of mammalian cells can be inhibited by agents which mimic or produce increases in the intracellular levels of cyclic 3′,5′-adenosine monophosphate (cyclic AMP)1,2. Goldberg and coworkers3,4 have proposed that in a number of cell types cyclic 3′,5′-guanosine monophosphate (cyclic GMP) promotes cellular events that are antagonistic to those ...
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Cyclic AMP and cyclic GMP in hyperresponsiveness
Life Sciences, 1988Cyclic-AMP has been shown to cause a hyperresponse in blood pressure change in conjunction with norepinephrine in the anesthetized rat system. Recent experiments show that the antagonist to angiotensin II, Sar1-Thr8 angiotensin II, abolishes the hyperresponse produced by c-AMP.
Herman T. Miller +3 more
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Neurochemistry International, 2004
The biokinetics of guanosine 3',5'-cyclic monophosphate (cGMP) is characterized by three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged cGMP by transport proteins in the cell membrane.
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The biokinetics of guanosine 3',5'-cyclic monophosphate (cGMP) is characterized by three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged cGMP by transport proteins in the cell membrane.
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Cyclic GMP signaling in podocytes
Microscopy Research and Technique, 2002AbstractNatriuretic peptides (NP), together with nitric oxide (NO) are powerful relaxing factors acting via a common second messenger, cyclic GMP (cGMP). Together with other vasoactive modulators, these vasorelaxing factors play an essential role in regulating the function of kidney glomeruli.
Barbara Lewko, Jan Stepinski
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Annual Review of Pharmacology, 1974
A chapter on "Cyclic AMP and Drug Action" has already been published in Annual Review of Pharmacology (1). In spite of its restrictive title, this paper covered most of the knowledge about the biochemical and biological effects of cAMP that was available in 1969.
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A chapter on "Cyclic AMP and Drug Action" has already been published in Annual Review of Pharmacology (1). In spite of its restrictive title, this paper covered most of the knowledge about the biochemical and biological effects of cAMP that was available in 1969.
openaire +2 more sources
Cyclic GMP and photoreceptor function
The FASEB Journal, 1990A single photon can be detected by a rod photoreceptor cell. The absorption of light by rhodopsin triggers a cascade of reactions that amplifies the photon signal and results in ion channel closure with hyperpolarization of the rod photoreceptor cell.
Richard N. Lolley, R. H. Lee
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Annual Review of Neuroscience, 1986
Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
openaire +2 more sources