Results 301 to 310 of about 72,449 (334)

The role of cyclic AMP and cyclic GMP in byssinosis

American Industrial Hygiene Association Journal, 1979
The lungs of female guinea pigs, either untreated or previously sensitized with aqueous extracts of cotton dust (AECD) were perfused via the pulmonary artery with 0, 10-6, 10-5 or 10-4 g/mL of lyophilized AECD in Tyrodes solution. Pressure changes in the pulmonary artery were monitored during this period.
Gerald A. Greenblatt, M H Elissalde
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Acetylcholine and Cyclic GMP [PDF]

, 1978
This article examines some of the evidence for or against the hypothesis that guanosine 3′,5′-cyelic monophosphate (cGMP) is the intracellular mediator of the actions of acetylcholine (ACh), with particular emphasis on the situation in the mammalian nervous system.
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Clinical Relationships of Cyclic GMP

1994
Publisher Summary The purpose of this chapter is to review current knowledge on the clinical use of cyclic guanosine monophosphate (cGMP) measurements as markers of endogenous and exogenous ANP effects. cGMP production through the stimulation of particulate guanylate cyclase is induced by the action of atrial natriuretic peptide (ANP) on target cells.
Jolanta Gutkowska, Ernesto L. Schiffrin, Pavel Hamet, Johanne Tremblay, Pierre Larochelle, Jean R. Cusson   +5 more
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The measurement of cyclic GMP and cyclic AMP phosphodiesterases

Analytical Biochemistry, 1979
Abstract Methods are described for measuring phosphodiesterases for cGMP and cAMP in the range of activity yielding 10 −12 to 10 −8 mol of product. The 5′-GMP formed is measured by conversion to GDP with guanylate kinase. Amounts of GDP greater than 10 −10 mol are measured directly with an enzyme system which results in stoichiometric oxidation of
Joyce G. Carter, Sosamma J. Berger, Oliver H. Lowry   +2 more
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Cyclic GMP metabolism in macrophages

Cellular Immunology, 1980
Abstract Levels of guanosine 3′,5′-cyclic monophosphate (cGMP) were determined by radioimmunoassay in adherence-purified, oil-induced guinea pig peritoneal exudate macrophages, after extraction of the cells with perchloric acid, purification on Dowex AG1-X8, and acetylation.
Edgar Pick, Yael Bromberg
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Cyclic GMP in Lower Forms

1994
Publisher Summary This chapter focuses on the lower forms of life—that is, single-celled organisms. It briefly reviews the literature on cyclic guanosine monophosphate (cGMP) in bacteria and then describes two systems that have been studied frequently—the slime mold ( Dictyostelium discoideum ) and the protozoans ( Paramecium and Tetrahymena ). The
Susanne Klumpp, Joachim E. Schultz
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Cyclic GMP System in the Epidermis

2015
A great deal of knowledge has been gained concerning the activation of adenylate and guanylate cyclase in epidermal cells. Adenylate cyclase is activated by 4 different independent receptors-responding respectively to catecholamine (beta), to prostaglandins (E), to histamine (H2), and to adenosine and it phosphorylated derivatives.
T Aoyagi, Hajime Iizuka, K Adachi, V Levin, K M Halprin   +4 more
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Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

European Journal of Biochemistry, 2003
Here, we show that recombinant bovine PDE5A1 is proteolysed by recombinant caspase‐3 in in vitro and transfected Cos‐7 cells. In addition, the treatment of PDE5A1‐transfected Cos‐7 and PC12 cells with staurosporine, an apoptotic agent that activates endogenous caspase‐3, also induced proteolysis and inactivation of PDE5A1.
Frame, Mhairi J, Tate, Rothwelle, Adams, David R, Morgan, Keith M, Houslay, M D, Vandenabeele, Peter, Pyne, Nigel J   +6 more
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Cyclic GMP and mechanisms of vasodilation

Pharmacology & Therapeutics, 1989
This review is the result of a widening interest in the role of cGMP in vascular smooth muscle function. Smooth muscle physiologists, pharmacologists, and biochemists now appreciate the fact that cGMP plays a key role in regulating vascular, and probably non-vascular, smooth muscle contractile ...
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Cyclic GMP-Hydrolyzing Phosphodiesterases

2009
The cyclic nucleotides (cN), cAMP and cGMP, are key second messengers that mediate the intracellular effects of many signals known as “first messengers”, including environmental signals such as photons for vision and chemicals for taste, as well as hormones, paracrine factors, neurotransmitters, or autocrine factors.
Erwin Bischoff, Sharron H. Francis, Jackie D. Corbin   +2 more
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