Results 311 to 320 of about 72,449 (334)

Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1984
Autophosphorylation of cyclic GMP-dependent protein kinase (GMP:protein phosphotransferase, EC 2.7.1.37) in the presence of cyclic AMP and Mg-ATP has already been shown to result in the incorporation of up to 2.6 mol phosphate per mol subunit and decrease the A0.5 for cyclic AMP approx. 10-fold.
Franz Hofmann, Brian A. Hemmings, Alastair Aitken   +2 more
openaire   +3 more sources

Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase

Nature, 1990
Atrial natriuretic peptide, acting through its second messenger guanosine 3',5'-cyclic monophosphate (cGMP), suppresses Na+ absorption across the renal inner-medullary collecting duct and increases urinary Na+ excretion. Patch clamp studies show that cGMP reduces Na+ absorption by inhibiting an amiloride-sensitive cation channel in the apical membrane.
Douglas B. Light, Bruce A. Stanton, Jackie D. Corbin   +2 more
openaire   +3 more sources

Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis

1994
Several of the different PDE isozyme families have the ability in vitro to hydrolyze cGMP. In particular they include the CaM-dependent PDEs, the cGMP-stimulated PDEs, and the cGMP binding, cGMP-specific PDEs. Existing evidence suggests or demonstrates that in different cell types, each of these can be important determinants for the control of cGMP ...
Joseph A. Beavo, William K. Sonnenburg
openaire   +3 more sources

Platelet Cyclic GMP Responses to Nitroglycerin

Cardiovascular Drugs and Therapy, 2000
The present study further investigates the use of platelet cyclic guanosine monophosphate (GMP) as a biochemical measure of tolerance. Platelet cyclic GMP has been reported as a marker of the biochemical effects of nitroglycerin (GTN) and as an indicator of the development of tolerance.
John D. Parker, Jeffrey S. Tong, Douglas D. Martin   +2 more
openaire   +3 more sources

Involvement of Cyclic GMP in Nitric-Oxide-induced Gastric Relaxation: Comparison of the Actions of Cyclic GMP and Cyclic AMP

Scandinavian Journal of Gastroenterology, 2001
Smooth muscle relaxation induced by various agents that increase the cellular levels of cyclic nucleotides (cAMP and cGMP) is accompanied by a decrease in intracellular Ca2+ concentration. However, little is known about the differences between the inhibitory effects of cAMP and cGMP on the contraction of smooth muscle.To compare the effects and ...
D. S. Min, Y.-H. Jo, J.-C. Choi, S. H. Yoon, S. S. Sim, S. J. Hahn, Min Sung Kim, Duck-Joo Rhie, Y.-C. Kim, H.-S. Shim   +9 more
openaire   +3 more sources

Cyclic di-GMP as a second messenger

Current Opinion in Microbiology, 2006
In many bacteria bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) signaling determines the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis. Thereby, the tightly regulated temporal and spatial activity patterns of GGDEF and EAL domain proteins, which synthesize and degrade c-di-GMP,
Dorit Amikam, Ute Römling
openaire   +3 more sources

Effect of Cyclic GMP on Intestinal Transport

1994
Publisher Summary Cyclic guanosine monophosphate (cGMP) was established as an important regulator of intestinal ion transport in the late seventies, when it was shown to be the intracellular mediator of salt and water secretion induced by Escherichia coli heat-stable enterotoxin (STa).
Arie B. Vaandrager, Hugo R. de Jonge
openaire   +4 more sources

Intracellular cyclic GMP receptor proteins

The FASEB Journal, 1993
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated ion channels, and cGMP-regulated cyclic nucleotide phosphodiesterases.
Trudy L. Cornwell, Thomas M. Lincoln
openaire   +3 more sources

[12] Assay of cyclic GMP by activation of cyclic GMP-dependent protein kinase

1974
Publisher Summary The assay method is based upon the ability of low concentrations of cyclic GMP (eGMP) to activate cyclic GMP-dependent protein kinases, which catalyze the phosphorylation of substrate proteins (e.g., histone, protamine) by ATP. Under the standard assay conditions, the extent of histone phosphorylation is directly proportional to the
Paul Greengard, J.F. Kuo
openaire   +2 more sources

Cyclic GMP Signaling

2017
Guanosine 3′5′ cyclic monophosphate (cGMP) is synthesized by soluble guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric oxide (NO) and nitrovasodilators and by particulate guanylate cyclases (pGC) when stimulated with natriuretic peptides.
openaire   +3 more sources