Results 91 to 100 of about 965,975 (328)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Tuning Nanoscale Conductance in Cyclic Molecules via Molecular Length and Anchoring Groups

open access: yesNanomaterials
This theoretical study investigates the electrical conductance of non-conjugated cyclic molecules featuring three terminal anchoring groups at the single-molecule level. Density Functional Theory (DFT) calculations demonstrate that the conductance of the
Abdullah Alshehab   +2 more
doaj   +1 more source

Cyclic homology and group actions [PDF]

open access: yesJournal of Geometry and Physics, 2018
v2: final version. To appear in J. Geom. Phys.
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Planning of physical load of annual cycle of students’, practicing cyclic kinds of sports, training

open access: yesPhysical Education of Students, 2017
Purpose: to offer the variant of physical load’s distribution in annual cycle of students’, practicing cyclic kinds of sports training. Material: in the research pedagogic HEE students, specializing in skiing and light athletic participated (n=18 - boys,
R.S. Nagovitsyn   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

On cohomologies and extensions of cyclic groups

open access: yesTopology and its Applications, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Golasiński, Marek   +1 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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