Results 231 to 240 of about 965,975 (328)

Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference. [PDF]

Proc Natl Acad Sci U S A
Sundman AK, Binford GJ, Montfort WR, Cordes MHJ.   +3 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Ring-opening decarbonylative C(sp³)-C(sp³) cross-electrophile coupling of cyclic imides with unactivated alkyl chlorides. [PDF]

Chem Sci
Lentelink NJ, Pânzar PMF, Rowlinson NAV, Morandi B.   +3 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Functional Effects of Cyclization on Li1 Peptide Activity against Metacyclic <i>Leishmania amazonensis</i> Internalization. [PDF]

ACS Omega
Reis TC, Yagi ACL, Velásquez AMA, Dias Ramos AL, Costa Coelho NC, Cilli EM, Graminha MAS.   +6 more
europepmc   +1 more source

ON THE NUMBER OF CYCLIC SUBGROUPS OF A GROUP [PDF]

Proceedings of the National Academy of Sciences, 1929
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Umpolung strategy for the electrochemical synthesis of novel anthraquinone-based sulfonamide derivatives: a facile and sustainable strategy. [PDF]

RSC Adv
Nematollahi D, Mohamadighader N, Zivari-Moshfegh F.   +2 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source