Results 51 to 60 of about 84,969 (338)
American Journal of Respiratory Cell and Molecular Biology, 2013 Pulmonary hypertension (PH) occurs in 25 to 35% of premature infants with significant bronchopulmonary dysplasia (BPD). Neonatal mice exposed to 14 days of hyperoxia develop BPD-like lung injury and PH.
Keng Jin Lee +6 more
semanticscholar +1 more source
Nucleotides function as endogenous chemical sensors for oxidative stress signaling [PDF]
, 2010 Oxidized and nitrated nucleotides including 8-oxogunanine and 8-nitroguanine derivatives such as 8-nitroguanosine 3',5'-cyclic monophosphate were generated by reactive nitrogen oxides and reactive oxygen species in cultured cells and in tissues.
Akaike, Takaaki +3 more
core +2 more sources
Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
Molecules, 2011 Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear.
Xuming Deng +6 more
doaj +1 more source
Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
, 2018 Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
core +2 more sources
Gastroenterology, 2013 BACKGROUND & AIMS Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C).
J. Castro +18 more
semanticscholar +1 more source
Urinary excretion of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate in malignancy. [PDF]
Journal of Clinical Pathology, 1978 The urinary excretion of cyclic adenosine 3',5'-monophosphate (cAMP), corrected for urinary creatinine, was determined in 177 patients with primary or metastatic tumours and in 149 normal subjects. In 26 patients with malignancy and in 10 control subjects the excretion of cyclic guanosine 3',5'-monophosphate (cGMP) was also evaluated.
Gennari, C. +3 more
openaire +5 more sources
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Neural Regeneration ResearchInterferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou +10 more
doaj +1 more source
Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis
Animal Cells and Systems, 2021 Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and internal organs. Despite the recent advances in the pathogenesis and treatment of SSc, effective therapies for fibrosis caused by SSc have not yet been ...
Jong Seong Roh +6 more
doaj +1 more source
The T2238C human atrial natriuretic peptide molecular variant and the risk of cardiovascular diseases [PDF]
, 2018 Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene.
Bianchi, Franca +5 more
core +2 more sources