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Cyclic Guanosine Monophosphate Modulation and Blood Pressure [PDF]
Hypertension, 2014 See related article, pp 1241–1247 Few intracellular second messengers received more attention in cardiovascular basic and clinical research than cyclic GMP (cGMP). Guanylyl cyclases produce cGMP from its precursor molecule, guanosine triphosphate.
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCyclic guanosine monophosphate‐protein kinase G‐phosphodiesterase 5 signaling may be disturbed in heart failure (HF) with preserved ejection fraction, contributing to cardiac remodeling and dysfunction.
Jessica A. Hiemstra +18 more
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Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes [PDF]
Circulation, 2006 Background— Cyclic guanosine monophosphate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides, such as atrial or brain natriuretic peptide, which activate the soluble and particulate forms of guanylyl cyclase, respectively.
Castro, Liliana +3 more
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Journal of Ginseng Research, 2017 Background: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism.
Hang Xiao +3 more
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Vinpocetine is the forthcoming adjuvant agent in the management of COVID-19
Future Science OA, 2022 Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1 that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN have anti-inflammatory and antioxidant effects with suppression release of pro-
Hayder M Al-kuraishy +3 more
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Cyclic guanosine monophosphate improves salt tolerance in Solanum lycopersicum. [PDF]
J Plant Res, 2023 AbstractThe cyclic nucleotide cyclic guanosine monophosphate (cGMP) is a powerful cell signaling molecule involved in biotic and abiotic stress perception and signal transduction. In the model plant Arabidopsis thaliana, salt and osmotic stress rapidly induce increase in cGMP which plays role by modulating the activity of monovalent cation transporters,
Bibi G +8 more
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Effects of cyclic nucleotides on midgut infections and maturation of
Parasites & Vectors, 2008 Cyclic nucleotide signalling through cyclic adenosine monophosphate (cAMP) is thought to play an important role in the transformation of the long slender (dividing) form to the short-stumpy (arrested) form in the mammalian bloodstream but the role of ...
Maudlin Ian +2 more
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Journal of Biological Chemistry, 1980 The hydrolysis of cGMP by phosphodiesterase was conducted in [18O]water to determine the site of bond cleavage and the stoichiometry of 18O incorporation into 5'-GMP. Three different forms of phosphodiesterase including a calmodulin-calcium-dependent enzyme in its basal and activated states were examined. The hydrolysis of cGMP catalyzed by each of the
N D, Goldberg +4 more
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Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production
Frontiers in Microbiology, 2021 Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. Nevertheless, it is not known whether Brucella spp.
Ruizhen Li +9 more
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Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis
Memorias do Instituto Oswaldo Cruz, 2003 Although there are some data concerning the nitric oxide and the cyclic 3'-5'guanosine monophosphate (cGMP) signaling pathway in trypanosomatids, there is no report about the cGMP-dependent enzymatic activity identification.
LF Géigel, LL Leon
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