Results 1 to 10 of about 1,641 (118)

Cyclic GMP and Cilia Motility [PDF]

Cells, 2015
Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense.
Todd A. Wyatt
doaj   +3 more sources

Yin and Yang of Biofilm Formation and Cyclic di-GMP Signaling of the Gastrointestinal Pathogen Salmonella enterica Serovar Typhimurium

Journal of Innate Immunity, 2021
Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by nutrient sources; these investigations produced new dogmas such as cyclic diguanylate monophosphate (cyclic di-GMP)
Agaristi Lamprokostopoulou, Ute Römling
doaj   +1 more source

Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone

Nature Communications, 2022
Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS ...
Shuyu Li, Hengxi Sun, Jianghan Li, Yujiao Zhao, Ruiying Wang, Lei Xu, Chongyi Duan, Jialin Li, Zhuo Wang, Qinmeng Liu, Yao Wang, Songying Ouyang, Xihui Shen, Lei Zhang   +13 more
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Specificity of the cyclic GMP-bbmding activity and of a cyclic GMP-dependent cyclic GMP phosphodiesterase in Dictyostelium discoideum [PDF]

Molecular and Cellular Endocrinology, 1982
The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6 = O, N7, 2(1)-OH and 3(1)-O and ...
Haastert, Peter J.M. van, Walsum, Hans van, Meer, Rob C. van der, Bulgakov, Roman, Konijn, Theo M.   +4 more
openaire   +3 more sources

The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis

Frontiers in Pharmacology, 2022
The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation.
Yuliang Liu, Yuliang Liu, Yuliang Liu, Yihui Li, Yihui Li, Yihui Li, Li Xue, Li Xue, Li Xue, Jie Xiao, Jie Xiao, Jie Xiao, Pengyong Li, Pengyong Li, Pengyong Li, Wanlin Xue, Wanlin Xue, Wanlin Xue, Chen Li, Chen Li, Chen Li, Haipeng Guo, Haipeng Guo, Haipeng Guo, Yuguo Chen, Yuguo Chen, Yuguo Chen   +26 more
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Crystal structure and functional implication of bacterial STING

Nature Communications, 2022
The bacterial Cyclic-oligonucleotide-Based Anti-phage Signaling System (CBASS) contains a CD-NTase that synthesizes cyclic di- and tri-nucleotides, and bacterial STING proteins recognize c-di-GMP generated by CD-NTase during phage infection and signal ...
Tzu-Ping Ko, Yu-Chuan Wang, Chia-Shin Yang, Mei-Hui Hou, Chao-Jung Chen, Yi-Fang Chiu, Yeh Chen   +6 more
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Dissecting the molecular dance: c-di-GMP, cAMP-CRP, and VfmH collaboration in pectate lyase regulation for Dickeya dadantii—unveiling the soft rot pathogen’s strategy

Microbiology Spectrum, 2023
Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee, Xiaochen Yuan, Ching-Hong Yang   +2 more
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Identification of a cyclic-di-GMP-modulating response regulator that impacts biofilm formation in a model sulfate reducing bacterium

Frontiers in Microbiology, 2014
We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev, Eric G Luning, Sara eAltenburg, Grant Matthew Zane, Edward E Baidoo, Michela eCatena, Jay D Keasling, Jay D Keasling, Judy D Wall, Matthew W Fields, Aindrila eMukhopadhyay   +10 more
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RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. [PDF]

PLoS ONE, 2012
Biofilm formation and dispersal in the black rot pathogen Xanthomonas campestris pathovar campestris (Xcc) is influenced by a number of factors. The extracellular mannanase ManA has been implicated in biofilm dispersal whereas biofilm formation requires ...
Xiu-Hong Lu, Shi-Qi An, Dong-Jie Tang, Yvonne McCarthy, Ji-Liang Tang, John Maxwell Dow, Robert P Ryan   +6 more
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Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence.

PLoS Pathogens, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Shi-qi An, Delphine L Caly, Yvonne McCarthy, Sarah L Murdoch, Joseph Ward, Melanie Febrer, J Maxwell Dow, Robert P Ryan   +7 more
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