Cyclic di-GMP: second messenger extraordinaire [PDF]
Nature Reviews Microbiology, 2017 Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP). Known since the late 1980s, it is now recognized as a near-ubiquitous second messenger that coordinates diverse aspects of bacterial growth and behaviour, including ...
Urs Jenal, Jenal Urs
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Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens [PDF]
mSystems, 2022 Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
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Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm in Synechococcus elongatus PCC 7942 [PDF]
Journal of BacteriologyIn phototrophic cyanobacteria, the signaling molecule bis-(3′-5′)-cyclic dimeric-guanosine monophosphate (c-di-GMP) plays important roles in a wide variety of functions associated with environmental conditions, including biofilm formation, motility ...
Chihiro C. Yamaguchi +12 more
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Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria [PDF]
Nature CommunicationsCyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the ...
Xiaocui Ling +10 more
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Controlling Biofilm Development Through Cyclic di-GMP Signaling. [PDF]
Adv Exp Med Biol, 2022 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date summary of c-di-GMP pathways connected to biofilm formation by the opportunistic pathogen P ...
Park S, Sauer K.
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Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [PDF]
Microbial BiotechnologyThe second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino +5 more
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Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms. [PDF]
Nat Microbiol, 2023 Gomez JB, Waters CM.
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Journal of Innate Immunity, 2021 Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by nutrient sources; these investigations produced new dogmas such as cyclic diguanylate monophosphate (cyclic di-GMP)
Agaristi Lamprokostopoulou, Ute Römling
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Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Nature Communications, 2022 Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS ...
Shuyu Li +13 more
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Allosteric Control of Cyclic di-GMP Signaling [PDF]
Journal of Biological Chemistry, 2006 Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host. Although the enzymes responsible for the regulation of cellular levels of c-di-GMP, diguanylate cyclases (DGC) and phosphodiesterases, have been identified ...
Christen, B. +7 more
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