Cyclic di-GMP: second messenger extraordinaire [PDF]
Nature Reviews Microbiology, 2017 Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP).
Urs Jenal
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Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence. [PDF]
PLoS Pathogens, 2014 Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Shi-qi An +7 more
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Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens [PDF]
mSystems, 2022 Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
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Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm in Synechococcus elongatus PCC 7942 [PDF]
Journal of BacteriologyIn phototrophic cyanobacteria, the signaling molecule bis-(3′-5′)-cyclic dimeric-guanosine monophosphate (c-di-GMP) plays important roles in a wide variety of functions associated with environmental conditions, including biofilm formation, motility ...
Chihiro C. Yamaguchi +12 more
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Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria [PDF]
Nature CommunicationsCyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the ...
Xiaocui Ling +10 more
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Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [PDF]
Microbial BiotechnologyThe second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino +5 more
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Journal of Innate Immunity, 2021 Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by nutrient sources; these investigations produced new dogmas such as cyclic diguanylate monophosphate (cyclic di-GMP)
Agaristi Lamprokostopoulou, Ute Römling
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Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Nature Communications, 2022 Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS ...
Shuyu Li +13 more
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Microbiology Spectrum, 2023 Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee +2 more
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Crystal structure and functional implication of bacterial STING
Nature Communications, 2022 The bacterial Cyclic-oligonucleotide-Based Anti-phage Signaling System (CBASS) contains a CD-NTase that synthesizes cyclic di- and tri-nucleotides, and bacterial STING proteins recognize c-di-GMP generated by CD-NTase during phage infection and signal ...
Tzu-Ping Ko +6 more
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