Results 1 to 10 of about 13,509,513 (296)

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence. [PDF]

PLoS Pathogens, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Shi-qi An, Delphine L Caly, Yvonne McCarthy, Sarah L Murdoch, Joseph Ward, Melanie Febrer, J Maxwell Dow, Robert P Ryan   +7 more
doaj   +2 more sources

Nucleotides as Bacterial Second Messengers

Molecules, 2023
In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz, Claudia Guerrero-Barajas, Gabriel Betanzos-Cabrera, Juan C. Cancino-Diaz   +3 more
doaj   +1 more source

Identification of a cyclic-di-GMP-modulating response regulator that impacts biofilm formation in a model sulfate reducing bacterium

Frontiers in Microbiology, 2014
We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev, Eric G Luning, Sara eAltenburg, Grant Matthew Zane, Edward E Baidoo, Michela eCatena, Jay D Keasling, Jay D Keasling, Judy D Wall, Matthew W Fields, Aindrila eMukhopadhyay   +10 more
doaj   +1 more source

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

eLife, 2014
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments.
Debashree Chatterjee, Richard B Cooley, Chelsea D Boyd, Ryan A Mehl, George A O'Toole, Holger Sondermann   +5 more
doaj   +1 more source

Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming

mBio, 2022
Bacterial motility has great medical and ecological significance because of its essential role in bacterial survival and pathogenesis. Cyclic dimeric GMP (c-di-GMP), a second messenger in bacteria, is the predominant regulator of flagellar synthesis and ...
Xin Zhang, Yan Wang, Yao Wu, Zhi-Hui Yuan, Zhen Cai, Wei Qian, Xin Ge, Fang-Fang Wang   +7 more
doaj   +1 more source

RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. [PDF]

PLoS ONE, 2012
Biofilm formation and dispersal in the black rot pathogen Xanthomonas campestris pathovar campestris (Xcc) is influenced by a number of factors. The extracellular mannanase ManA has been implicated in biofilm dispersal whereas biofilm formation requires ...
Xiu-Hong Lu, Shi-Qi An, Dong-Jie Tang, Yvonne McCarthy, Ji-Liang Tang, John Maxwell Dow, Robert P Ryan   +6 more
doaj   +1 more source

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective

mBio, 2013
Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a
Marco Agostoni, Benjamin J. Koestler, Christopher M. Waters, Barry L. Williams, Beronda L. Montgomery   +4 more
doaj   +1 more source

c-di-GMP Inhibits Early Sporulation in Clostridioides difficile

mSphere, 2021
The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo   +4 more
doaj   +1 more source

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

PLoS ONE, 2013
The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines.
Guanghui Yi, Volker P Brendel, Chang Shu, Pingwei Li, Satheesh Palanathan, C Cheng Kao   +5 more
doaj   +1 more source

The HD-GYP Domain, Cyclic Di-GMP Signaling, and Bacterial Virulence to Plants

Molecular Plant-Microbe Interactions, 2006
Cyclic di-GMP is an almost ubiquitous second messenger in bacteria that was first described as an allosteric activator of cellulose synthase but is now known to regulate a range of functions, including virulence in human and animal pathogens. Two protein
J. Maxwell Dow, Yvonne Fouhy, Jean F. Lucey, Robert P. Ryan   +3 more
doaj   +1 more source