Principles of c-di-GMP signaling : characterization of a second messenger system orchestrating bacterial life style [PDF]
, 2007 Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities, known as biofilms, that colonize surfaces.
Christen, Beat
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Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]
, 2009 Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
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The HD-GYP Domain, Cyclic Di-GMP Signaling, and Bacterial Virulence to Plants
Molecular Plant-Microbe Interactions, 2006 Cyclic di-GMP is an almost ubiquitous second messenger in bacteria that was first described as an allosteric activator of cellulose synthase but is now known to regulate a range of functions, including virulence in human and animal pathogens. Two protein
J. Maxwell Dow +3 more
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Shining the Light on Cyclic di-GMP Dark Matter [PDF]
Journal of Bacteriology, 2018 ABSTRACT Bacterial cyclic di-GMP signaling networks often consist of dozens of components, and the majority of these components have no observable function. Dahlstrom et al. (J. Bacteriol. 200:e00703-17, 2018, https://doi.org/10.1128/JB.00703-17 ) explored the function of every component of the
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, 2022 Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Joey Kuok Hoong Yam (6295388) +9 more
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Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
Journal of Oral Microbiology, 2019 Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi +5 more
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Visualization of c-di-GMP in multicellular Dictyostelium stages
Frontiers in Cell and Developmental Biology, 2023 The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes.
Hayato Ide +3 more
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Tracking the homeostasis of second messenger cyclic-di-GMP in bacteria [PDF]
Biophysical Reviews, 2020 Cyclic-di-GMP (c-di-GMP) is an important second messenger in bacteria which regulates the bacterial transition from motile to sessile phase and also plays a major role in processes such as cell division, exopolysaccharide synthesis, and biofilm formation. Due to its crucial role in dictating the bacterial phenotype, the synthesis and hydrolysis of c-di-
Anushya Petchiappan +2 more
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Unconventional Cyclic di-GMP Signaling in Escherichia coli
, 2020 The species Escherichia coli represents an unfathomable variety of commensal, pathogenic, and environmental strains. The conventional cyclic di-GMP signaling in E.
Nikola Zlatkov +3 more
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The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]
, 2012 The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216) +48 more
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