Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP [PDF]
Nature Structural & Molecular Biology, 2014 The bacterial signaling molecule cyclic di-GMP (c-di-GMP) stimulates the synthesis of bacterial cellulose, which is frequently found in biofilms. Bacterial cellulose is synthesized and translocated across the inner membrane by a complex of cellulose synthase BcsA and BcsB subunits.
Morgan, Jacob L. W. +2 more
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The Regulation of Alginate Biosynthesis via Cyclic di-GMP Signaling
, 2020 Bacterial alginates are anionic exopolysaccharides, which are produced by Pseudomonas and Azotobacter species. Bacterial cells embedded in extracellular polymeric substances such as alginates have a survival advantage as they are protected against ...
Rehm, BHA +3 more
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Tracking the homeostasis of second messenger cyclic-di-GMP in bacteria [PDF]
Biophysical Reviews, 2020 Cyclic-di-GMP (c-di-GMP) is an important second messenger in bacteria which regulates the bacterial transition from motile to sessile phase and also plays a major role in processes such as cell division, exopolysaccharide synthesis, and biofilm formation. Due to its crucial role in dictating the bacterial phenotype, the synthesis and hydrolysis of c-di-
Anushya Petchiappan +2 more
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Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control [PDF]
, 2014 When Caulobacter crescentus enters S-phase the replication initiation inhibitor CtrA dynamically positions to the old cell pole to be degraded by the polar ClpXP protease.
Ebbensgaard, Anna Elisabeth +14 more
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Cyclic di-GMP Regulates Motility, Biofilm Formation, and Desiccation Tolerance in Acinetobacter baumannii [PDF]
, 2022 Acinetobacter baumannii is an increasingly multidrug-resistant pathogen contributing to hospital-acquired infections necessitating the discovery of novel treatments.
Reynolds, Garrett
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Controlling Biofilm Development Through Cyclic di-GMP Signaling. [PDF]
Adv Exp Med Biol, 2022 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date summary of c-di-GMP pathways connected to biofilm formation by the opportunistic pathogen P ...
Park S, Sauer K.
europepmc +3 more sources
Shining the Light on Cyclic di-GMP Dark Matter [PDF]
Journal of Bacteriology, 2018 ABSTRACT Bacterial cyclic di-GMP signaling networks often consist of dozens of components, and the majority of these components have no observable function. Dahlstrom et al. (J. Bacteriol. 200:e00703-17, 2018, https://doi.org/10.1128/JB.00703-17 ) explored the function of every component of the
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Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
Journal of Oral Microbiology, 2019 Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi +5 more
doaj +1 more source
Extraction and Quantification of Cyclic Di-GMP from Pseudomonas aeruginosa
Bio-Protocol, 2013 Cyclic di-GMP (c-di-GMP) has emerged as an important intracellular signaling molecule, controlling the transitions between planktonic (free-living) and sessile lifestyles, biofilm formation, and virulence in a wide variety of microorganisms.
Ankita Roy, Olga Petrova, Karin Sauer
doaj +1 more source
Visualization of c-di-GMP in multicellular Dictyostelium stages
Frontiers in Cell and Developmental Biology, 2023 The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes.
Hayato Ide +3 more
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