Results 51 to 60 of about 13,509,513 (296)

Unconventional Cyclic di-GMP Signaling in Escherichia coli

, 2020
The species Escherichia coli represents an unfathomable variety of commensal, pathogenic, and environmental strains. The conventional cyclic di-GMP signaling in E.
Nikola Zlatkov, Uhlin, Bernt Eric,, Bernt Eric Uhlin, Zlatkov, Nikola,   +3 more
core   +1 more source

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. [PDF]

, 2012
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3.
Ouyang, Songying, Zhiqiang Zhang, Iyer, Shankar S, Schenk, Mirjam, Liu, Zhi-Jie, Zhong, Wenwan, Parvatiyar, Kislay, Mirjam Schenk, Yong-jun Liu, Zaver, Shivam A, Kislay Parvatiyar, Liu, Yong-jun, Genhong Cheng, Jiang, Yan, Zeng, Shang, Modlin, Robert L, Songying Ouyang, Yan Jiang, Wenwan Zhong, Cheng, Genhong, Teles, Rosane M, Robert L Modlin, Zhi-Jie Liu, Shivam A Zaver, Shang Zeng, Rosane M Teles, Zhang, Zhiqiang, Shankar S Iyer   +27 more
core   +2 more sources

Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. [PDF]

PLoS Pathogens, 2012
The second messenger, cyclic diguanylate (c-di-GMP), regulates diverse cellular processes in bacteria. C-di-GMP is produced by diguanylate cyclases (DGCs), degraded by phosphodiesterases (PDEs), and receptors couple c-di-GMP production to cellular ...
Nicholas J Shikuma, Jiunn C N Fong, Fitnat H Yildiz   +2 more
doaj   +1 more source

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator

, 2014
Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina, Keevil, Charles William, Schlaefli, Henry George, Webb, Jeremy Stephen, Tews, Ivo, Phippen, Curtis William   +5 more
core   +1 more source

Cyclic-di-GMP Regulates Salmonella Typhimurium Infection of Epithelial Cells and Macrophages [PDF]

, 2023
Regulation of the bacterial second messenger cyclic-di-GMP in Salmonella Typhimurium allows it to delicately alter phenotypes to optimize invasion and survive intracellularly in epithelial cells and macrophages to become virulent and cause infection ...
Musa, Abdulafiz
core   +1 more source

Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain

Nature Communications, 2016
Cyclic-di-GMP is a bacterial second messenger that binds to the regulatory domain of ATPases of some bacteria. Here, the authors report the crystal structure of this interaction, identify a cyclic-di-GMP binding mode, and show that this interaction might
Yu-Chuan Wang, Ko-Hsin Chin, Zhi-Le Tu, Jin He, Christopher J. Jones, David Zamorano Sanchez, Fitnat H. Yildiz, Michael Y. Galperin, Shan-Ho Chou   +8 more
doaj   +1 more source

Bacterial cyclic diguanylate signaling networks sense temperature

Nature Communications, 2021
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility ...
Henrik Almblad, Trevor E. Randall, Fanny Liu, Katherine Leblanc, Ryan A. Groves, Weerayuth Kittichotirat, Geoffrey L. Winsor, Nicolas Fournier, Emily Au, Julie Groizeleau, Jacquelyn D. Rich, Yuefei Lou, Elise Granton, Laura K. Jennings, Larissa A. Singletary, Tara M. L. Winstone, Nathan M. Good, Roger E. Bumgarner, Michael F. Hynes, Manu Singh, Maria Silvina Stietz, Fiona S. L. Brinkman, Ayush Kumar, Ann Karen Cornelia Brassinga, Matthew R. Parsek, Boo Shan Tseng, Ian A. Lewis, Bryan G. Yipp, Justin L. MacCallum, Joe Jonathan Harrison   +29 more
doaj   +1 more source

Principles of c-di-GMP signaling : characterization of a second messenger system orchestrating bacterial life style [PDF]

, 2007
Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities, known as biofilms, that colonize surfaces.
Christen, Beat
core   +1 more source

Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]

, 2009
Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
core   +1 more source

Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch

Molecules, 2012
C-di-GMP, a cyclic guanine dinucleotide, has been shown to regulate biofilm formation as well as virulence gene expression in a variety of bacteria. Analogues of c-di-GMP have the potential to be used as chemical probes to study c-di-GMP signaling and ...
Herman O. Sintim, Nirmal Pahadi, Jingxin Wang, David A. Sayre, Jie Zhou   +4 more
doaj   +1 more source