Results 71 to 80 of about 13,509,513 (296)

Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems

Cell Communication and Signaling, 2023
Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes.
Fazlurrahman Khan, Geum-Jae Jeong, Nazia Tabassum, Young-Mog Kim   +3 more
doaj   +1 more source

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP [PDF]

Science, 2008
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression.
N, Sudarsan, E R, Lee, Z, Weinberg, R H, Moy, J N, Kim, K H, Link, R R, Breaker   +6 more
openaire   +2 more sources

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella

Nature Communications, 2023
Cyclic di-GMP (c-di-GMP) is a second messenger that transduces extracellular stimuli into cellular responses and regulates various biological processes in bacteria. H-NS is a global regulatory protein that represses expression of many genes, but how H-NS
Shuyu Li, Qinmeng Liu, Chongyi Duan, Jialin Li, Hengxi Sun, Lei Xu, Qiao Yang, Yao Wang, Xihui Shen, Lei Zhang   +9 more
doaj   +1 more source

The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]

, 2012
The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216), Jenal Urs, Jacob G. Malone (158210), Blanka Andrea, Pablo Manfredi, Andrea Blanka, Guy R. Cornelis, Jacob G. Malone, Jaeger Tina, Cornelis Guy R., Bos, R., Manfredi, Pablo, Jacob G Malone, Dötsch, A., Jaeger, T., Blanka, A., Pablo Manfredi (158219), Cornelis, Guy R, Manfredi, P., Bos Raphael, Andrea Blanka (158227), Raphael Bos (158229), Jenal, Urs, Jaeger, Tina, Tina Jaeger, Malone, Jacob G., Urs Jenal (37942), Jenal, U., Blanka, Andrea, Malone Jacob G., Dötsch Andreas, Susanne Häussler (158235), Urs Jenal, Häussler, S., Andreas Dötsch, Cornelis, Guy R., Susanne Häussler, Häussler, Susanne, Manfredi Pablo, Häussler Susanne, Raphael Bos, Guy R. Cornelis (158232), Guy R Cornelis, Malone, Jacob G, Dötsch, Andreas, Cornelis, G. R., Andreas Dötsch (158223), Bos, Raphael, Malone, J. G., Bos R, Cornelis GR, Jenal U, Malone JG, Manfredi P, Jaeger T, Dötsch A, Blanka A, Häussler S   +57 more
core   +1 more source

Table_1_Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes.docx

, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Joey Kuok Hoong Yam (6295388), Xianghui Liu (493570), Michael Givskov (235463), Jaime Brizuela (13138524), Corina Hadjicharalambous (13138527), Scott A. Rice (143316), Adeline Mei Hui Yong (13138521), Richard Morton (3448070), Alain Filloux (190708), Kira Eilers (13138518)   +9 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts

Cell Reports
Summary: It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestines of hosts.
Mingfang Wang, Jia Zeng, Binbin Cui, Guangliang Wu, Xiayu Chen, Yikai Fu, Bing Gu, Yinyue Deng   +7 more
doaj   +1 more source

Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation

Frontiers in Chemistry, 2020
The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho, R. Grant Tryon, Jeong-Ho Kim   +2 more
doaj   +1 more source