Results 71 to 80 of about 16,264 (303)

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation

Frontiers in Chemistry, 2020
The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho, R. Grant Tryon, Jeong-Ho Kim   +2 more
doaj   +1 more source

c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella

Nature Communications, 2023
Cyclic di-GMP (c-di-GMP) is a second messenger that transduces extracellular stimuli into cellular responses and regulates various biological processes in bacteria. H-NS is a global regulatory protein that represses expression of many genes, but how H-NS
Shuyu Li, Qinmeng Liu, Chongyi Duan, Jialin Li, Hengxi Sun, Lei Xu, Qiao Yang, Yao Wang, Xihui Shen, Lei Zhang   +9 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts

Cell Reports
Summary: It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestines of hosts.
Mingfang Wang, Jia Zeng, Binbin Cui, Guangliang Wu, Xiayu Chen, Yikai Fu, Bing Gu, Yinyue Deng   +7 more
doaj   +1 more source

A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins

Bio-Protocol, 2015
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many processes in bacteria including biofilm formation, motility, and virulence (Hengge, 2009). Analysis of c-di-GMP binding properties of bacterial proteins is an important step to
Disha Srivastava, Christopher Waters
doaj   +1 more source

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems. [PDF]

PLoS Pathogens, 2015
Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins.
Kevin G Roelofs, Christopher J Jones, Sarah R Helman, Xiaoran Shang, Mona W Orr, Jonathan R Goodson, Michael Y Galperin, Fitnat H Yildiz, Vincent T Lee   +8 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Surface sensing for biofilm formation in Pseudomonas aeruginosa [PDF]

, 2017
YesAggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial behaviors under various conditions. In clinical settings, persistent presence of biofilms increases the risks of healthcare-associated infections and imposes ...
Alexander, Ali-Ahmad, Alm, Baker, Baraquet, Baraquet, Barken, Belete, Bernier, Bhagirath, Breidenstein, Buensuceso, Caiazza, Chambonnier, Chua, Crouzet, Davies, De, Dötsch, Fata Moradali, Flemming, Fulcher, Galperin, Guilbaud, Gupta, Gupta, Güvener, Hancock, Heacock-Kang, Heiniger, Hengge, Hickman, Hickman, Hook, Hook, Huangyutitham, Irie, Jain, Johnson, Jones, Kanack, Kong, Kuchma, Kuchma, Kuchma, Kulasekara, Lapouge, Lee, Leighton, Li, Liao, Lin Chua, Luo, McCarter, Merighi, Merritt, Merritt, Mesaros, Mikkelsen, Monds, Moradali, Moscoso, Moscoso, Nadal Jimenez, Oglesby, Olsen, Orans, Patell, Percival, Persat, Poole, Rao, Ribbe, Rodesney, Romling, Rosenthal, Russotto, Siryaporn, Smith, Stewart, Su, Tuson, Ueda, Ueda, Vakulskas, Valentini, van Schaik, Wei, Whitchurch, Whitchurch, Winsor, Wolfgang, Wood, Wood, Yu   +94 more
core   +2 more sources

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP [PDF]

Science, 2008
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression.
N, Sudarsan, E R, Lee, Z, Weinberg, R H, Moy, J N, Kim, K H, Link, R R, Breaker   +6 more
openaire   +2 more sources