Results 91 to 100 of about 16,264 (303)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

mBio, 2010
The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt, Dae-Gon Ha, Kimberly N. Cowles, Wenyun Lu, Diana K. Morales, Joshua Rabinowitz, Zemer Gitai, George A. O’Toole   +7 more
doaj   +1 more source

Denitrification-derived nitric oxide modulates biofilm formation in Azospirillum brasilense [PDF]

, 2013
Azospirillum brasilense is a rhizobacterium that provides beneficial effects on plants when they colonize roots. The formation of complex bacterial communities known as biofilms begins with the interaction of planktonic cells with surfaces in response to
Arruebarrena Di Palma, Andrés, Baca, Beatriz E., Creus, Cecilia Mónica, Lamattina, Lamattina, Moreno Ramírez, Lizbeth, Pereyra, Cintia Mariana, Pereyra, María Alejandra, Xiqui Vazquez, Maria L.   +7 more
core   +1 more source

Cyclic di-GMP Positively Regulates DNA Repair in Vibrio cholerae [PDF]

Journal of Bacteriology, 2018
Vibrio cholerae is a prominent human pathogen that is currently causing a pandemic outbreak in Haiti, Yemen, and Ethiopia. The second messenger molecule cyclic di-GMP (c-di-GMP) mediates the transitions in V. cholerae between a sessile biofilm-forming state and a motile lifestyle, both of which are ...
Nicolas L, Fernandez, Disha, Srivastava, Amanda L, Ngouajio, Christopher M, Waters   +3 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

New insights into Legionella pneumophila biofilm regulation by c-di-GMP signaling [PDF]

, 2016
The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), a bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) and
Allombert, Julie, Doublet, Patricia, Lajoie Halova, Barbora, Pécastaings, Sophie, Roques, Christine, Vianney, Anne   +5 more
core   +3 more sources

Cyclic Di-GMP Modulates the Disease Progression of Erwinia amylovora [PDF]

Journal of Bacteriology, 2013
ABSTRACT The second messenger cyclic di-GMP (c-di-GMP) is a nearly ubiquitous intracellular signal molecule known to regulate various cellular processes, including biofilm formation, motility, and virulence. The intracellular concentration of c-di-GMP is inversely governed by diguanylate cyclase (DGC) enzymes and ...
Adam C, Edmunds, Luisa F, Castiblanco, George W, Sundin, Christopher M, Waters   +3 more
openaire   +3 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Regulation by cyclic di-GMP in Myxococcus xanthus

, 2016
The nucleotide-based second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) is involved in regulating a plethora of processes in bacteria that are typically associated with lifestyle changes. Myxococcus xanthus undergoes major lifestyle changes in response to nutrient availability with the formation of spreading colonies in the presence of ...
Skotnicka, Dorota, Søgaard-Andersen, Lotte (Prof. Dr.)   +1 more
openaire   +3 more sources

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]

, 2018
Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F., Giardina, G., Janson, G., Leoni, L., Mantoni, F., Paiardini, A., Paone, A., Rampioni, G., Rinaldo, S.   +8 more
core   +1 more source