Results 111 to 120 of about 13,509,513 (296)

Cyclic di-GMP-Responsive Transcriptional Reporter Bioassays in \u27Pseudomonas aeruginosa\u27

, 2017
3′,5′-cyclic diguanosine monophosphate (cyclic di-GMP) is a bacterial secondary messenger molecule that regulates many important cellular activities and behaviors, such as motility and biofilm formation. While mass spectrometry protocols for quantitative
Borlee, Grace I., Irie, Yasuhiko, Martin, Kevin H., Borlee, Bradley R., Sauer, Karin.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service)   +5 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Cyclic di-GMP biosensor [Dataset]

A—Cyclic di-GMP levels in WT AB5075, WT overexpressing constitutively active DGC gene pleD* (WT+pleD*) and WT with empty miniTn7 used for the strain construction.
McCarthy, Ronan R., Rubio, Alejandro, Dios, Rubén de, Harkova, Lyuboslava G., Pérez-Pulido, Antonio J.   +4 more
core   +1 more source

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

, 2013
Cyclic guanosine 3',5'-monophosphate (cyclic GMP) is a second messenger whose role in bacterial signalling is poorly understood. A genetic screen in the plant pathogen Xanthomonas campestris (Xcc) identified that XC_0250, which encodes a protein with a ...
Maxwell Dow, J., Yang, Jauo-Guey, Liu, Chung-Liang, An, Shi-Qi, Jauo-Guey Yang, Shan-Ho Chou, Dow, J. Maxwell, Chou, Shan-Ho, Ryan, Robert P., David Swarbreck, An, Shi Qi, Swarbreck, David, Jauo‐Guey Yang, Robert P Ryan, Chou, Shan Ho, J Maxwell Dow, Jane Rogers, Liu, Chung Liang, Shi‐Qi An, Yang, Jauo Guey, Yvonne McCarthy, McCarthy, Yvonne, Chin, Ko-Hsin, Shan‐Ho Chou, Melanie Febrer, Ko‐Hsin Chin, Chung-Liang Liu, Chin, Ko Hsin, Rogers, Jane, Ryan, Robert P, Shi-Qi An, Febrer, Melanie, Chung‐Liang Liu, Ko-Hsin Chin   +33 more
core   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
doaj   +1 more source

The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP): Structure-Function Relationships

Biosensors, 2013
Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP) is a heme-based O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic-di-GMP to linear di-GMP.
Toru Shimizu
doaj   +1 more source

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP

, 2016
Cyclic dinucleotides are an important class of signaling molecules that regulate a wide variety of pathogenic responses in bacteria, but tools for monitoring their regulation in vivo are lacking.
Colleen A. Kellenberger (1340292), Jade Sales-Lee (761232), Stephen C. Wilson (1974652), Ming C. Hammond (761236)   +3 more
core   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Second Messenger Cyclic-di-GMP Regulation in Acinetobacter baumannii [PDF]

, 2020
Over time, “superbugs,” or bacteria that have become resistant to antibiotics, have become a great concern in modern medicine. Viable alternates are currently being looked into as effective and safe ways to prevent or treat infections caused by these ...
Deal, Justin
core   +1 more source