Results 131 to 140 of about 13,509,513 (296)
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source
Regulation by cyclic di-GMP in Myxococcus xanthus
, 2016 The nucleotide-based second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) is involved in regulating a plethora of processes in bacteria that are typically associated with lifestyle changes. Myxococcus xanthus undergoes major lifestyle changes in response to nutrient availability with the formation of spreading colonies in the presence of ...
openaire +3 more sources
The structral aspects of cyclic GMP and cyclic di-GMP-dependent bacterial signaling pathways
, 2015 二級訊息傳導物質Cyclic guanosine 3',5'-monophosphate (cyclic GMP) 在細菌訊號傳遞中所扮演的功能在過去並非相當明確。然而在植物病原菌Xanthomonas campestris pv campestris (Xcc)的基因篩選實驗中發現，編碼XC_0250會轉譯出第三型nucleotidyl 環化酶，並合成cyclic GMP。在in vitro的實驗也證實純化出來的XC_0250具有合成cyclic GMP的能力。而其相連的基因XC_0249 ...
楊詔貴, Jauo-Guey Yang
core
Advanced Science, EarlyView.RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He +12 more
wiley +1 more source
Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c‐di‐GMP effector BerB
MicrobiologyOpen, 2017 Knowledge about the molecular mechanisms that are involved in the regulation of biofilm formation is essential for the development of biofilm‐control measures.
Mustafa Fazli +13 more
doaj +1 more source
Binding of XC_2801//XC_3703 to the flhBA promoter is modulated by cyclic di-GMP.
, 2014 (A). The impact of various concentrations of cyclic di-GMP on the binding of XC_2801//XC_3703 to the flhBA promoter was assessed by the use of electromobility shift assay (EMSA).
Sarah L. Murdoch (645976) +7 more
core +1 more source
Advanced Science, EarlyView.A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao +12 more
wiley +1 more source
Changes in concentration of second messenger cyclic di-GMP when Nostoc cyanobacteria form hormogonia
, 2019 In this research project the changes in concentration of second messenger cyclic di-GMP when Nostoc cyanobacteria form hormogonia were examined. Hormogonia filaments are able to glide with type IV pili towards hormogonia inducing factors.
Reynir Freyr Reynisson 1979-
core +2 more sources
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source