Results 121 to 130 of about 16,264 (303)

Regulating STING in health and disease. [PDF]

, 2017
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named "STimulator of INterferon Genes (STING)".
A Ablasser, A Fiszer-Kierzkowska, A Nazmi, A Takaoka, AC Collins, AG York, AH Rahman, AJ Sadler, AJ Schmidt, AK Lakkaraju, AN Harman, AP West, B Vries de, B Zhong, B Zhong, BA Diner, BW Davies, C Castanier, C Enevold, C Flück, C Günther, C Kooten van, C Shu, C Wolf, CHA Tang, CK Holm, CK Holm, CK Holm, D Bansal, D Cuchet-Lourenco, D Gao, D Gao, D Zhu, DH Barouch, DH Nguyen, DJ Gough, DJ Wallace, DL Burdette, DW Hommes, E Lam, E Lee, E Meylan, EE Gray, EG Boyce, EJ Diner, EN Benveniste, Endre Kiss-Toth, F Martínez Valle, G Surpris, G Trinchieri, G Uzé, GI Rice, GI Rice, GJ Seo, GN Barber, H Chen, H Chen, H Guo, H Ishikawa, H Ishikawa, H Ishikawa, H Miyabe, H Oda, Heather L. Wilson, HHL Borba, I Kamga, J Ahn, J Diamond, J Fu, J Goverman, J Klarquist, J Langhorne, J Lippmann, J Wu, J Wu, JC Ravenscroft, JD Sauer, JE Hagstrom, JE Vance, JJ Woodward, JJ Wu, JM Tran Janco, JT Merrill, JW Schoggins, K Eguchi, K Maringer, K Miyamoto, K Nagasawa, K Saukkonen, KG Lee, KJ Mackenzie, KY Su, L Corrales, L Deng, L Ding, L Jin, L Jin, L Jin, L Jin, L Lau, L Li, L Sun, L Unterholzner, L Zhang, L-G Xu, LAJ O’Neill, LB Ivashkiv, M Blanc, M Chawla-Sarkar, M Christen, M Kalamvoki, M Lolicato, M Zheng, M-L Frémond, MC Gauzzi, MH Christensen, MH Christensen, MJ Veer de, MK Atianand, MK Crow, ML Yarbrough, MP Rodero, MR Arbuckle, MR Jakobsen, MR Thompson, MS Diamond, N Au-Yeung, N Gratz, N Jeremiah, N Kerur, N Ranganath, N Yan, NF Moore, P Gao, P Gao, Q Liang, Q Wang, Q Yin, R Furie, R Salloum, RB Seth, RO Watson, RO Watson, S Barman, S Liu, S Marchi, S Nitta, S Ouyang, S Sharma, SB Rasmussen, SR Woo, SR Woo, T Abe, T Abe, T Doyle, T Kawai, T Li, T Nakamura, T Tsuchida, TB Niewold, TM Allen, U Koppe, U Ravnskov, V Dell’Oste, V Hornung, V Pokatayev, VP Torchilin, VR DeFilippis, W Sun, W Zhang, WM Schneider, X Lahaye, X Li, X Yu, X Zhang, Y Bai, Y Kai Chan, Y Liu, Y Liu, Y Tanaka, Y-H Huang, Yang Li, YH Chiu, YJ Crow, Z Liao, Z Ma, Z Zhang, Z Zhang   +187 more
core   +2 more sources

Cyclic di‐GMP, an established secondary messenger still speeding up [PDF]

Environmental Microbiology, 2011
Summary The secondary messenger cyclic di‐GMP coordinately regulates the transition between motility/sessility/virulence in bacterial populations and upon adaptation to novel habitats. Thereby, multiple independent regulatory circuits regulate a diversity of targets.
openaire   +2 more sources

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans

Pathogens
Cyclic di-GMP (bis-(3′→5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation.
Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Gabriela Roberto Silva, Cauê Augusto Boneto Gonçalves, Daniel Enrique Sanchez-Limache, Bruna Sayuri Cardoso Ogusku, Anacleto Silva de Souza, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +9 more
doaj   +1 more source

The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP): Structure-Function Relationships

Biosensors, 2013
Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP) is a heme-based O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic-di-GMP to linear di-GMP.
Toru Shimizu
doaj   +1 more source

Cyclic-di-GMP Reaches Out into the Bacterial RNA World

Science Signaling, 2010
A bacterial second messenger regulates mRNA translation by altering the cleavage of a self-splicing intron.
openaire   +2 more sources

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
doaj   +1 more source

The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility.

PLoS Genetics, 2016
The molecular basis of second messenger signaling relies on an array of proteins that synthesize, degrade or bind the molecule to produce coherent functional outputs.
Martina Valentini, Benoît-Joseph Laventie, Joana Moscoso, Urs Jenal, Alain Filloux   +4 more
doaj   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source