Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms [PDF]
Journal of Bacteriology, 2016 ABSTRACT Cyclic di-GMP (c-di-GMP) synthetases and hydrolases (GGDEF, EAL, and HD-GYP domains) can be readily identified in bacterial genome sequences by using standard bioinformatic tools. In contrast, identification of c-di-GMP receptors remains a difficult task, and the current list of experimentally characterized c-di-GMP-binding proteins ...
Shan-Ho Chou, Michael Y. Galperin
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Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective
mBio, 2013 Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a
Marco Agostoni +4 more
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Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]
, 2018 Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon +6 more
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Discovery of the Second Messenger Cyclic di-GMP [PDF]
, 2017 The nearly ubiquitous bacterial second messenger cyclic di-GMP is involved in a multitude of fundamental physiological processes such as sessility/motility transition and the switch between the acute and chronic infection status, combined with cell cycle control.
Ute, Römling, Michael Y, Galperin
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c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
mSphere, 2021 The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards +4 more
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Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]
, 2019 The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R. +12 more
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Cyclic‐di‐GMP regulation of virulence in bacterial pathogens [PDF]
WIREs RNA, 2017 Signaling pathways allow bacteria to adapt to changing environments. For pathogenic bacteria, signaling pathways allow for timely expression of virulence factors and the repression of antivirulence factors within the mammalian host. As the bacteria exit the mammalian host, signaling pathways enable the expression of factors promoting survival in the ...
Cherisse L, Hall, Vincent T, Lee
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PLoS ONE, 2013 The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines.
Guanghui Yi +5 more
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Getting Wrinkly Spreaders to demonstrate evolution in schools [PDF]
, 2014 Understanding evolution is crucial to modern biology,but most teachers would assume that practical demonstrations of evolution in school laboratories are unfeasible.
Spiers, Andrew J.
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Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide [PDF]
Scientific Reports, 2017 AbstractTuberculosis is still on the top of infectious diseases list on both mobility and mortality, especially due to drug-resistance of Mycobacterium tuberculosis (M.tb). Ethionamide (ETH) is one of effective second line anti-TB drugs, a synthetic compound similar to isoniazid (INH) structurally, with existing severe problem of ETH resistance. ETH is
Hai-Nan Zhang +11 more
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