Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas +2 more
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The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases. [PDF]
PLoS ONE, 2017 Globin-coupled diguanylate cyclases contain globin, middle, and diguanylate cyclase domains that sense O2 to synthesize c-di-GMP and regulate bacterial motility, biofilm formation, and virulence.
Xuehua Wan +4 more
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The enhanced expression of genes encoding diguanylate cyclases under cold stress contributes to the adhesion and biofilm formation of Shewanella putrefaciens WS13 [PDF]
Frontiers in Nutrition, 2022 Shewanella putrefaciens is a special spoilage bacterium of seafood during cold storage, which is easy to form biofilm and bring serious hazard to the seafood quality.
Ruheng Xiong +24 more
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Global Transcriptional Repression of Diguanylate Cyclases by MucR1 Is Essential for Sinorhizobium -Soybean Symbiosis [PDF]
mBio, 2021 The ubiquitous second messenger c-di-GMP is well-known for its role in biofilm formation and host adaptation of pathogens, whereas it is less investigated in mutualistic symbioses. Here, we reveal a cocktail of eight functional diguanylate cyclases (DGCs)
Meng-Lin Li +5 more
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Bioinformatic and functional characterization of cyclic-di-GMP metabolic proteins in Vibrio alginolyticus unveils key diguanylate cyclases controlling multiple biofilm-associated phenotypes [PDF]
Frontiers in Microbiology, 2023 The biofilm lifestyle is critical for bacterial survival and proliferation in the fluctuating marine environment. Cyclic diguanylate (c-di-GMP) is a key second messenger during bacterial adaptation to various environmental signals, which has been ...
Xiao-Xiao Gong +16 more
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Cyclic di-GMP Signaling in
mBio, 2020 Bacillus subtilis contains two known cyclic di-GMP (c-di-GMP)-dependent receptors, YdaK and DgrA, as well as three diguanylate cyclases (DGCs): soluble DgcP and membrane-integral DgcK and DgcW.
Sandra Kunz +5 more
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Functional Specialization in
mBio, 2019 Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels and/or activity of diguanylate cyclases (DGCs).
David Zamorano-Sánchez +7 more
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Flavonoids interfere with biofilm formation by targeting diguanylate cyclases in multidrug resistant Vibrio cholerae [PDF]
Scientific ReportsRise of antibiotic resistance has led to increased treatment failures in severe cholera cases across the globe. The etiological agent Vibrio cholerae is known for its ability to persist in human gut and environmental settings through biofilm formation ...
Tuhin Manna +11 more
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Multicellular String-Like Structure Formation by Salmonella Typhimurium Depends on Cellulose Production: Roles of Diguanylate Cyclases, YedQ and YfiN [PDF]
Frontiers in Microbiology, 2020 Bacteria face diverse stresses in the environment and, sometimes, respond by forming multi-cellular structures, e.g., biofilms. Here, we report a novel macroscopic and multi-cellular structure formed by Salmonella Typhimurium, which resembles small ...
Alan Varghese +3 more
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The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus [PDF]
Gut PathogensVibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue ...
Jhih-Ren Yang +3 more
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