Results 1 to 10 of about 3,903 (78)

Cyclic nucleotide specific phosphodiesterases of Leishmania major [PDF]

BMC Microbiology, 2006
Background Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human and mammalian hosts by different bloodsucking sandfly vectors.
Linder Markus, Kunz Stefan, Johner Andrea, Shakur Yasmin, Seebeck Thomas   +4 more
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New Avenues for Phosphodiesterase Inhibitors in Asthma

Journal of Experimental Pharmacology, 2021
Maria Gabriella Matera,1 Josuel Ora,2 Francesco Cavalli,2 Paola Rogliani,2,3 Mario Cazzola3 1Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Respiratory Diseases Unit, “Tor Vergata&rdquo ...
Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M   +4 more
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Cyclic Nucleotide Phosphodiesterase Families as Targets to Treat Pulmonary Arterial Hypertension: Beyond PDE5 Inhibitors?

Cells
Pulmonary arterial hypertension (PAH) is a fatal disease with no cure. Until recently, most specific therapies for PAH had aimed at enhancing cyclic nucleotide (cAMP and cGMP) pathways, taking advantage of the vasorelaxant and antiproliferative ...
Liting Wang, Rodolphe Fischmeister, Boris Manoury   +2 more
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Alterations of Phosphodiesterases in Adrenocortical Tumors

Frontiers in Endocrinology, 2016
Alterations in the cyclic (c) AMP-dependent signaling pathway have been implicated in the majority of benign adrenocortical tumors (ACTs) causing Cushing syndrome (CS).
Fady Hannah-Shmouni, Fabio Faucz, Constantine A. Stratakis   +2 more
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The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors

Biosensors
Phosphodiesterases (PDEs), a superfamily of enzymes that hydrolyze cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are recognized as a therapeutic target for various diseases.
Chunhua Gao, Zhe Wang, Xiaojing Liu, Rongzhen Sun, Shengyao Ma, Zongchen Ma, Qi Wang, Guoqiang Li, Han-Ting Zhang   +8 more
doaj   +1 more source

A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation

Frontiers in Immunology
T-cell activation is a pivotal process of the adaptive immune response with 3′,5′-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function.
Marie Bielenberg, Marie Bielenberg, Marie Bielenberg, Roberta Kurelic, Stefan Frantz, Stefan Frantz, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +7 more
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Aerobic granular sludge for complex heavy metal-containing wastewater treatment: characterization, performance, and mechanisms analysis

Frontiers in Microbiology
Complex heavy metal (HM)-containing wastewater discharges pose substantial risks to global water ecosystems and human health. Aerobic granular sludge (AGS) has attracted increased attention as an efficient and low-cost adsorbent in HM-containing ...
Chong Liu, Yao Shen, Yuguang Li, Fengguang Huang, Shuo Wang, Shuo Wang, Ji Li, Ji Li   +7 more
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Defining the Specialized Functions of cAMP Signals in an Organelle Formerly Deemed to Have No Function: The Primary Cilium

Function, 2023
Aldebaran M Hofer
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Transcriptional profiling of Pseudomonas aeruginosa biofilm life cycle stages reveals dispersal-specific biomarkers

Frontiers in Microbiology
Bacteria exhibit two lifestyles: planktonic, free-floating individual cells or sessile multicellular aggregates known as biofilms. The biofilm life cycle is characterized by three distinct stages: attachment, maturation and dispersal.
Xavier Bertran Forga, Xavier Bertran Forga, Kathryn E. Fairfull-Smith, Kathryn E. Fairfull-Smith, Jilong Qin, Jilong Qin, Makrina Totsika, Makrina Totsika   +7 more
doaj   +1 more source

Phosphodiesterases Inhibition by Bacilli Calmette-Guérin Contributes to Decrease Asthma in Allergic Rats

Iranian Journal of Allergy, Asthma and Immunology, 2011
Phosphodiesterases  (PDE)  hydrolyse intracellular cAMP  and  cGMP  to  inactive  5’ monophosphates. Decreased level of cAMP is involved in the pathogenesis of asthma.
Yajuan Wang, Yali Jiang, Huifang Tang, Xuefeng Wang, Chunzhen Zhao, Jiqiang Chen   +5 more
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