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Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases [PDF]
CellsThe phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases)
Christopher S. Vennard +2 more
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Phosphodiesterases in neurodegenerative disorders [PDF]
IUBMB Life, 2012 Cyclic nucleotide phosphodiesterases (PDEs) are responsible for the breakdown of cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).
Jos Prickaerts
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C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG [PDF]
PLoS ONE, 2013 In biofilms, the bacterial community optimizes the strategies to sense the environment and to communicate from cell to cell. A key player in the development of a bacterial biofilm is the second messenger c-di-GMP, whose intracellular levels are modulated
Giorgio Giardina +2 more
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Phosphodiesterases Expression during Murine Cardiac Development [PDF]
International Journal of Molecular Sciences, 2021 : 30-50 cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes playing a fundamental role in the control of intracellular levels of cAMP and cGMP. Emerging evidence suggested an important role of phosphodiesterases in heart formation,
Silvia Cardarelli +2 more
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Phosphodiesterases and cAMP Pathway in Pituitary Diseases [PDF]
Frontiers in Endocrinology, 2019 Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1–11), expressed in different tissues and cells, including heart and brain.
Mariana Ferreira Bizzi +4 more
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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases [PDF]
Frontiers in Endocrinology, 2023 The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan +4 more
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Cyclic nucleotide specific phosphodiesterases of
BMC Microbiology, 2006 Background Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human and mammalian hosts by different bloodsucking sandfly vectors.
Linder Markus +4 more
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Mammalian Glycerophosphodiester Phosphodiesterases [PDF]
Bioscience, Biotechnology and Biochemistry, 2007 Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol, which are utilized as major sources of carbon and phosphate.
Thanutchaporn Kumrungsee +1 more
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Pathogens, 2022 Phosphodiesterases are essential regulators of cyclic nucleotide signaling with diverse physiological functions. Two phosphodiesterases, PdeH and PdeL, have been identified from yeast and filamentous fungi.
Ni Ma +5 more
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Frontiers in Microbiology, 2010 The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi.
Charu eAgarwal +2 more
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