Results 21 to 30 of about 17,744 (296)

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms

Cells, 2023
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms.
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev   +6 more
doaj   +1 more source

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Frontiers in Pharmacology, 2022
Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad, Kaisun Nesa Lesa, Ari Sudarmanto, Nanang Fakhrudin, Nanang Fakhrudin, Zullies Ikawati   +5 more
doaj   +1 more source

Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies

Biology, 2023
Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes ...
Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili   +9 more
doaj   +1 more source

A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

Frontiers in Physiology, 2023
Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood ...
Evrim Goksel, Evrim Goksel, Evrim Goksel, Elif Ugurel, Elif Ugurel, Elie Nader, Elie Nader, Camille Boisson, Camille Boisson, Ingrid Muniansi, Ingrid Muniansi, Philippe Joly, Philippe Joly, Celine Renoux, Celine Renoux, Alexandra Gauthier, Philippe Connes, Philippe Connes, Ozlem Yalcin, Ozlem Yalcin   +19 more
doaj   +1 more source

Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis

Microorganisms, 2021
Diguanylate cyclases (DGCs) and phosphodiesterases (PDEs) are essential enzymes deputed to maintain the intracellular homeostasis of the second messenger cyclic dimeric (3′→5′) GMP (c-di-GMP).
Desirèe Nuzzo, Roman Makitrynskyy, Olga Tsypik, Andreas Bechthold   +3 more
doaj   +1 more source

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations [PDF]

, 2010
Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite ...
Terrin, A., Terrin, A, Zaccolo Manuela, Rodrigo F Oliveira, Oliveira Rodrigo F., Kim, M., Blackwell, K., Cannon, R.C., Kim T Blackwell, Oliveira, RF, Wonryull Koh, Di Benedetto Giulietta, Kim MyungSook, Giulietta Di Benedetto, Manuela Zaccolo, Zaccolo, M, Cannon, RC, Terrin Anna, MyungSook Kim, Zaccolo, Manuela, Anna Terrin, Robert C Cannon, Di Benedetto, G., Cannon Robert C., Koh, K., Robert C. Cannon, Di Benedetto, G, Koh Wonryull, Zaccolo, M., Koh, W, Blackwell Kim T., Kim T. Blackwell, Rodrigo F. Oliveira, Oliveira, R.F., Kim, M, Blackwell, KT   +35 more
core   +1 more source

Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection

Biomolecular Concepts, 2023
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus belonging to the coronavirus family responsible for coronavirus disease 2019 (COVID-19).
Giuzio Federica, Bonomo Maria Grazia, Catalano Alessia, Infantino Vittoria, Salzano Giovanni, Monné Magnus, Geronikaki Athina, Petrou Anthi, Aquaro Stefano, Sinicropi Maria Stefania, Saturnino Carmela   +10 more
doaj   +1 more source

Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection

Frontiers in Microbiology, 2018
Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species. The most common species, Leptospira interrogans, can transfer from contaminated soil or water to the human body.
Guohui Xiao, Liangliang Kong, Liangliang Kong, Rongbo Che, Yusi Yi, Qinchao Zhang, Jie Yan, Jie Yan, Xu'ai Lin, Xu'ai Lin   +9 more
doaj   +1 more source

The Sequence and a Three-Dimensional Structural Analysis Reveal Substrate Specificity among Snake Venom Phosphodiesterases

Toxins, 2019
(1) Background. Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes. In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysis ...
Anwar Ullah, Kifayat Ullah, Hamid Ali, Christian Betzel, Shafiq ur Rehman   +4 more
doaj   +1 more source

PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects [PDF]

, 2015
The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent cardiac
Handschin, Christoph, Fernández-Belda, Francisco, Pérez-Schindler, Joaquín, Fuente, Teodomiro, Hernandez-Cascales, Jesús, Soler, Fernando   +5 more
core   +1 more source