Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases
Biochemical and Biophysical Research Communications, 2002 We have compared selected biophysical properties of three phosphodiesterases, from Arabidopsis thaliana, Saccharomyces cerevisiae, and Escherichia coli.
Andreas Hofmann, Alexander Wlodawer
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Characterization and Modification of Light-Sensitive Phosphodiesterases from Choanoflagellates
Biomolecules, 2022 Enzyme rhodopsins, including cyclase opsins (Cyclops) and rhodopsin phosphodiesterases (RhoPDEs), were recently discovered in fungi, algae and protists. In contrast to the well-developed light-gated guanylyl/adenylyl cyclases as optogenetic tools, ideal ...
Yuehui Tian +3 more
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Oxygen-responsive KoBdcA/KoBdcB/KoBpdA system regulates c-di-GMP levels to control bacterial cellulose biosynthesis and motility in Kosakonia oryzendophytica FY-07 [PDF]
Microbiology SpectrumCyclic di-GMP (c-di-GMP) acts as a bacterial second messenger that regulates various physiological processes, including biofilm formation, motility, and virulence. It is synthesized by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs),
Xueqing Zhao +8 more
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Transcriptional profiling of Pseudomonas aeruginosa biofilm life cycle stages reveals dispersal-specific biomarkers [PDF]
Frontiers in MicrobiologyBacteria exhibit two lifestyles: planktonic, free-floating individual cells or sessile multicellular aggregates known as biofilms. The biofilm life cycle is characterized by three distinct stages: attachment, maturation and dispersal.
Xavier Bertran Forga +7 more
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A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation
Frontiers in ImmunologyT-cell activation is a pivotal process of the adaptive immune response with 3′,5′-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function.
Stefan Frantz +2 more
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cAMP Compartmentalisation in Human Myometrial Cells
Cells, 2023 Preterm birth is the leading cause of childhood mortality and morbidity. A better understanding of the processes that drive the onset of human labour is essential to reduce the adverse perinatal outcomes associated with dysfunctional labour.
Alice Varley +3 more
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Identification and characterization of a novel phosphodiesterase from the metagenome of an Indian coalbed. [PDF]
PLoS ONE, 2015 Phosphoesterases are involved in the degradation of organophosphorus compounds. Although phosphomonoesterases and phosphotriesterases have been studied in detail, studies on phosphodiesterases are rather limited.
Durgesh Narain Singh +5 more
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Molbank, 2022 We herein report on the synthesis of a pentacyclic triterpene functionalized through derivation of betulinic acid with hydroxybenzotriazole. The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum ...
Ai Jiang +6 more
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Phosphodiesterase inhibitors [PDF]
British Journal of Pharmacology, 2006 Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to be weak inhibitors of PDE, but to what extent this ...
Boswell-Smith, V, Spina, D, Page, C P
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