Results 11 to 20 of about 3,903 (78)

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases

Cells
The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases)
Christopher S. Vennard, Samson Marvellous Oladeji, Herman O. Sintim   +2 more
doaj   +2 more sources

Phosphodiesterases and cAMP Pathway in Pituitary Diseases [PDF]

Frontiers in Endocrinology, 2019
Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1–11), expressed in different tissues and cells, including heart and brain.
Mariana Ferreira Bizzi, Graeme B. Bolger, Graeme B. Bolger, Márta Korbonits, Antonio Ribeiro-Oliveira Jr.   +4 more
doaj   +2 more sources

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases [PDF]

Frontiers in Endocrinology, 2023
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan, Sanika Mohagaonkar, Sanika Mohagaonkar, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +4 more
doaj   +2 more sources

Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases

Frontiers in Microbiology, 2010
The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi.
Charu eAgarwal, David J Schultz, Michael H Perlin   +2 more
doaj   +2 more sources

Functional Analysis of Two Affinity cAMP Phosphodiesterases in the Nematode-Trapping Fungus Arthrobotrys oligospora

Pathogens, 2022
Phosphodiesterases are essential regulators of cyclic nucleotide signaling with diverse physiological functions. Two phosphodiesterases, PdeH and PdeL, have been identified from yeast and filamentous fungi.
Ni Ma, Ke-Xin Jiang, Na Bai, Dong-Ni Li, Ke-Qin Zhang, Jin-Kui Yang   +5 more
doaj   +2 more sources

AMPc i neuroinflamació: Identificació de proteïnes implicades en la regulació dels nivells d’AMPc en l’encefalomielitis autoimmune experimental [PDF]

, 2011
L'AMPc té un paper clau com a missatger intracel.lular regulant la transmissió dels senyals extracel•lulars en diferents teixits i controlant múltiples processos cel lulars.
Sanabra Palau, Cristina
core   +7 more sources

Characterization and Modification of Light-Sensitive Phosphodiesterases from Choanoflagellates

Biomolecules, 2022
Enzyme rhodopsins, including cyclase opsins (Cyclops) and rhodopsin phosphodiesterases (RhoPDEs), were recently discovered in fungi, algae and protists. In contrast to the well-developed light-gated guanylyl/adenylyl cyclases as optogenetic tools, ideal ...
Yuehui Tian, Shang Yang, Georg Nagel, Shiqiang Gao   +3 more
doaj   +2 more sources

cAMP Compartmentalisation in Human Myometrial Cells

Cells, 2023
Preterm birth is the leading cause of childhood mortality and morbidity. A better understanding of the processes that drive the onset of human labour is essential to reduce the adverse perinatal outcomes associated with dysfunctional labour.
Alice Varley, Andreas Koschinski, Mark R. Johnson, Manuela Zaccolo   +3 more
doaj   +1 more source

3-[(1H-Benzo[d][1,2,3]triazol-1-yl)oxy]propyl 9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate

Molbank, 2022
We herein report on the synthesis of a pentacyclic triterpene functionalized through derivation of betulinic acid with hydroxybenzotriazole. The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum ...
Ai Jiang, Margrate Anyanwu, Kafai Leong, Jinxin Li, Alessandra Gianoncelli, Paolo Coghi, Giovanni Ribaudo   +6 more
doaj   +1 more source

Multiple Isozymes of Cyclic Nucleotide Phosphodiesterases in the Rat [PDF]

, 1990
Cyclic nucleotide phosphodiesterases catalyse the hydrolysis of 3'5'-cyclic nucleotides, such as cyclic AMP and cyclic GMP, to produce 5'-derivatives.
Lavan, Brian Edward
core   +6 more sources