Results 41 to 50 of about 3,903 (78)

Viral Nucleases

Viruses, 2023
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]
Zhengqiang Wang, Robert J. Geraghty
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PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

eLife, 2017
cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), localise to specific subcellular domains within which they
Stefania Monterisi, Miguel J Lobo, Craig Livie, John C Castle, Michael Weinberger, George Baillie, Nicoletta C Surdo, Nshunge Musheshe, Alessandra Stangherlin, Eyal Gottlieb, Rory Maizels, Mario Bortolozzi, Massimo Micaroni, Manuela Zaccolo   +13 more
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An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium

Frontiers in Cell and Developmental Biology
Self-organized and excitable signaling activities play important roles in a wide range of cellular functions in eukaryotic and prokaryotic cells. Cells require signaling networks to communicate amongst themselves, but also for response to environmental ...
Pundrik Jaiswal, Netra Pal Meena, Fu-Sheng Chang, Xin-Hua Liao, Lou Kim, Alan R. Kimmel   +5 more
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C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG. [PDF]

PLoS ONE, 2013
In biofilms, the bacterial community optimizes the strategies to sense the environment and to communicate from cell to cell. A key player in the development of a bacterial biofilm is the second messenger c-di-GMP, whose intracellular levels are modulated
Valentina Stelitano, Giorgio Giardina, Alessandro Paiardini, Nicoletta Castiglione, Francesca Cutruzzolà, Serena Rinaldo   +5 more
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PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis

Cell Reports Medicine
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, associated with poor response to therapies and high mortality. We identify that phosphodiesterase 7A (PDE7A) is overexpressed in the majority of TNBCs, and a higher ...
Parmanand Malvi, Suresh Bugide, Roshan Dutta, Kiran Kumar Reddi, Yvonne J.K. Edwards, Kamaljeet Singh, Romi Gupta, Narendra Wajapeyee   +7 more
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mSphere of Influence: Compartmentalized cAMP signals in American trypanosomes

mSphere
Noelia Lander works on cell signaling in American trypanosomes and studies the role of cyclic adenosine monophosphate (cAMP) microdomains in environmental sensing and differentiation. In this mSphere of Influence, Dr.
Noelia Lander
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Using cAMP Sensors to Study Cardiac Nanodomains

Journal of Cardiovascular Development and Disease, 2018
3′,5′-cyclic adenosine monophosphate (cAMP) signalling plays a major role in the cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters.
Katharina Schleicher, Manuela Zaccolo
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Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes

Journal of Cardiovascular Development and Disease, 2017
Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs).
Joshua R. St. Clair, Eric D. Larson, Emily J. Sharpe, Zhandi Liao, Catherine Proenza   +4 more
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Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells

Frontiers in Pharmacology, 2015
Stimulation of cAMP signaling induces apoptosis in glucocorticoid-sensitive and resistant CEM leukemic and MM.1 multiple myeloma cell lines, and this effect is enhanced by dexamethasone in both glucocorticoid-sensitive cell types and in glucocorticoid ...
Hongli eDong, Michael E. Carlton, Adam eLerner, Paul Mark Epstein   +3 more
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Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.

Pharmacological Research, 2022
The increase in intracellular calcium is influenced by cyclic nucleotides (cAMP and cGMP) content, which rating is governed by phosphodiesterases (PDEs) activity.Despite it has been demonstrated a beneficial effect of PDEs inhibitors in different ...
Valentina Vellecco, Elisabetta Panza, Sofia-Iris Bibli, Gian Marco Casillo, Federica Raucci, Onorina Laura Manzo, Martina Smimmo, Romolo Villani, Maria Rosaria Cavezza, Ingrid Fleming, Roberta d'Emmanuele di Villa Bianca, Francesco Maione, Giuseppe Cirino, Mariarosaria Bucci   +13 more
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