Results 61 to 70 of about 3,903 (78)

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K., Mackie, S., Houslay, M. D., Porteous, D.J., Hill, E. V., Hill, E.V., Porteous, D. J., Bolger, G.B., Murdoch, H., Klussmann, E., Collins, D. M., Millar, J. K., Bolger, G. B., Houslay, M.D., Collins, D.M.   +14 more
core   +1 more source

The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells

Computational and Structural Biotechnology Journal, 2020
Cyclic nucleotide signaling is pivotal to the asexual reproduction of Toxoplasma gondii, however little do we know about the phosphodiesterase enzymes in this widespread obligate intracellular parasite.
Kim Chi Vo, Özlem Günay-Esiyok, Nicolas Liem, Nishith Gupta   +3 more
doaj   +1 more source

Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets [PDF]

, 2012
The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir of new potential drug targets ...
de Koning, H., De Koning, H.P., Tenor, H., Kunz, S., Sterk, G.J., Gould, M.K., Seebeck, T., Gould, M., Luginbuehl, E.   +8 more
core   +2 more sources

Oxygen-responsive KoBdcA/KoBdcB/KoBpdA system regulates c-di-GMP levels to control bacterial cellulose biosynthesis and motility in Kosakonia oryzendophytica FY-07

Microbiology Spectrum
Cyclic di-GMP (c-di-GMP) acts as a bacterial second messenger that regulates various physiological processes, including biofilm formation, motility, and virulence. It is synthesized by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs),
Xueqing Zhao, Yucheng Shi, Wenzhuo Tian, Yutong Tian, Chuxiao Hu, Ziye Guo, Ting Ma, Guoqiang Li, Ge Gao   +8 more
doaj   +1 more source

Erectile Dysfunction Drugs as Potential Therapy for Cognitive Decline: Preclinical and Translational Evidence

Cells
Erectile dysfunction (ED) and cognitive decline share overlapping vascular, metabolic, and neurodegenerative mechanisms, particularly in aging populations.
Roberta Ricciarelli
doaj   +1 more source

General base-guanidinium cooperation in bifunctional artificial phosphodiesterases

, 2011
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP).
Cacciapaglia R., Salvio R., Mandolini L.
core   +2 more sources

Identification and partial characterization of cAMP-phosphodiesterases in the ciliate Euplotes raikovi. [PDF]

, 2004
In the ciliate Euplotes raikovi, two specific isoforms of cAMP- dependent phosphodiesterases were identified, one in the soluble and the other in the particulate fraction of the cell. Their activity was shown to be stimulated by Mg2+, insensitive to Ca2+
VALLESI, Adriana, APONE F, DI PRETORO B
core   +1 more source

Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

, 2002
We have compared selected biophysical properties of three phosphodiesterases, from Arabidopsis thaliana, Saccharomyces cerevisiae, and Escherichia coli.
Filipowicz, Witold, Hofmann, A, Grella, Melissa, Filipowicz, W, Wlodawer, A, Hofmann, Andreas, Nasr, Fahd, Ruvinov, S, Ruvinov, Sergei, Grella, M, Nasr, F, Tarasov, S, Wlodawer, Alexander, Tarasov, Sergey   +13 more
core   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

General Base–Guanidinium Cooperation in Bifunctional Artificial Phosphodiesterases

, 2016
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP).
Riccardo Salvio (1672393), Roberta Cacciapaglia (1672387), Luigi Mandolini (1641916)   +2 more
core   +1 more source