Results 61 to 70 of about 17,744 (296)

Using cAMP Sensors to Study Cardiac Nanodomains

Journal of Cardiovascular Development and Disease, 2018
3′,5′-cyclic adenosine monophosphate (cAMP) signalling plays a major role in the cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters.
Katharina Schleicher, Manuela Zaccolo
doaj   +1 more source

A PURIFICATION OF VENOM PHOSPHODIESTERASE

Journal of Biological Chemistry, 1952
For purposes of analysis of polynucleotides, it is desirable to have a phosphodiesterase, substantially free of 5-nucleotidase or other phosphatase activity. The presence of a phosphodiesterase in a wide variety of snake venoms was demonstrated by Gullan and Jackson (1). These venoms were found also to contain a potent 5-nucleotidase, but were free of
R L, SINSHEIMER, J F, KOERNER
openaire   +2 more sources

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes

Journal of Cardiovascular Development and Disease, 2017
Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs).
Joshua R. St. Clair, Eric D. Larson, Emily J. Sharpe, Zhandi Liao, Catherine Proenza   +4 more
doaj   +1 more source

Characterization of horse thyroid cyclic nucleotide phosphodiesterases.

, 1980
Cyclic nucleotide phosphodiesterases have been characterized in crude soluble extract (100000 ×g supernatant) of horse thyroid. DEAE‐cellulose ion‐exchange chromatography at pH 7.4 followed by ultracentrifugation on sucrose‐density gradients separated ...
Dumont, Jacques Emile, Couchie, D, Erneux, Christophe   +2 more
core   +1 more source

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K., Mackie, S., Houslay, M. D., Porteous, D.J., Hill, E. V., Hill, E.V., Porteous, D. J., Bolger, G.B., Murdoch, H., Klussmann, E., Collins, D. M., Millar, J. K., Bolger, G. B., Houslay, M.D., Collins, D.M.   +14 more
core   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells

Frontiers in Pharmacology, 2015
Stimulation of cAMP signaling induces apoptosis in glucocorticoid-sensitive and resistant CEM leukemic and MM.1 multiple myeloma cell lines, and this effect is enhanced by dexamethasone in both glucocorticoid-sensitive cell types and in glucocorticoid ...
Hongli eDong, Michael E. Carlton, Adam eLerner, Paul Mark Epstein   +3 more
doaj   +1 more source

Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.

Pharmacological Research, 2022
The increase in intracellular calcium is influenced by cyclic nucleotides (cAMP and cGMP) content, which rating is governed by phosphodiesterases (PDEs) activity.Despite it has been demonstrated a beneficial effect of PDEs inhibitors in different ...
Valentina Vellecco, Elisabetta Panza, Sofia-Iris Bibli, Gian Marco Casillo, Federica Raucci, Onorina Laura Manzo, Martina Smimmo, Romolo Villani, Maria Rosaria Cavezza, Ingrid Fleming, Roberta d'Emmanuele di Villa Bianca, Francesco Maione, Giuseppe Cirino, Mariarosaria Bucci   +13 more
doaj   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source