Results 71 to 78 of about 3,903 (78)

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

, 2014
Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept
Zaccolo, M, Lomas, O, Zaccolo, Manuela
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Architectures of cyclic dinucleotide phosphodiesterases of different classes.

, 2016
For comparison with CpdB, six proteins representative of previously known cyclic dinucleotide phosphodiesterases are shown with their catalytic domains highlighted (grey): two EAL domain proteins of different architecture, a membrane-bound and a soluble ...
Alicia Cabezas (148477), João Meireles Ribeiro (148483), Iralis López-Villamizar (693558), José Canales (148471), José Carlos Cameselle (148494), Rosa María Pinto (693559), María Jesús Costas (148489)   +6 more
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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

, 1995
In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases. In particular, the accumulating data showing that there are a large number of different phosphodiesterase isozymes have triggered an ...
J. A. Beavo
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Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Meyer, M. F., Schulz-Knappe, P., Forssmann, W. G., Stief, Christian Georg, Taher, A., Jonas, Udo, Truss, Michael C., C.G. Stief, A. Taher, P. Schulz-Knappe, M. Meyer, U. Jonas, M. Truss, W.-G. Forssmann   +13 more
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Partial purification and characterization of cyclic AMP phosphodiesterases from Funaria hygrometrica

, 1982
Cyclic AMP phosphodiesterase activity from chloronema cells of the moss Funaria hygrometrica has been purified 86-fold. This preparation contains more than a single phosphodiesterase activity since it hydrolyzes both 3', 5'-cAMP and 2', 3'-cAMP. It shows
Sharma, Shobhona, Johri, Man Mohan
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Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

, 2010
The aim of the present study was to evaluate the role of the nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction in a model of levodopa-induced dyskinesia in experimental parkinsonism.
Calabresi, Paolo, Carmela Giampà, Francesca R. Fusco, Massimiliano Di Filippo, Giampa', Carmela, Bagetta, Vincenza, Pendolino, Valentina, Paolo Calabresi, Carmelo Sgobio, Vincent Paillè, Picconi, Barbara, Di Filippo, Massimiliano, Sgobio, Carmelo, Alessandro Tozzi, Tozzi, Alessandro, Barbara Picconi, Valentina Pendolino, Paillé, Vincent, Giampà, Carmela, Fusco, Francesca, Ghiglieri, Veronica, Vincenza Bagetta, Veronica Ghiglieri   +22 more
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The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation

, 2001
The aim was to investigate the presence and activity of cGMP hydrolysing phosphodiesterases in guinea pig basilar arteries and the effect of selective and non-selective phosphodiesterase inhibitors on cerebral artery dilatation involving the nitric oxide
Edvinsson, L, Rybalkin, S D, Jansen-Olesen, I, Olesen, J., Khurana, T S, Kruuse, Christina   +5 more
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Isolation and characterization of insulin-stimulated, high-affinity cAMP phosphodiesterases from rat liver

, 1988
The ability of glucagon to elevate intracellular cAMP concentrations in hepatocytes is antagonized by insulin.l This effect is achieved through inhibition of adenylate cyclasC and activation of specific cAMP phosphodiesterases.
Pyne, N J, Cooper, M E, Houslay, M D
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