Results 51 to 60 of about 3,903 (78)
Frontiers in Physiology, 2018 Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca2+ releases (LCRs) from ryanodine receptors (RyR).
Tatiana M. Vinogradova +2 more
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Microorganisms, 2020 Cyclic di-adenosine monophosphate (c-di-AMP) has emerged as an important bacterial signaling molecule that functions both as an intracellular second messenger in bacterial cells and an extracellular ligand involved in bacteria-host cross-talk.
Gro Herredsvela Rørvik +7 more
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Kefir protects the liver against high fructose corn syrup induced phosphodiesterase hyperactivity
Türk Biyokimya Dergisi, 2022 Phosphodiesterases (PDEs) mediate several physiological activities, and alterations in PDE expressions might cause conflicts between functional and clinical effects.
Pektaş Mehmet Bilgehan +7 more
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, 2007 Cyclic nucleotide specific phosphodiesterases (PDEs) are pivotal regulators of cellular signaling. They are also important drug targets. Besides catalytic activity and substrate specificity, their subcellular localization and interaction with other cell ...
Baresic, Mario +5 more
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Multiple cyclic nucleotide phosphodiesterases in rat kidney [PDF]
, 1975 Multiple cyclic nucleotide phosphodiesterases in rat kidney. Using DEAE-cellulose chromatography and Agarose gel filtration we have partially purified a low Km cyclic adenosine monophosphate (AMP) phosphodiesterase from the 100,000 × g supernatant of rat
Farrand, J. Robert +2 more
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Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Frontiers in Pharmacology, 2015 During human placentation, mononuclear cytotrophoblasts fuse to form multinucleated syncytia ensuring hormonal production and nutrient exchanges between the maternal and fetal circulation. Syncytial formation is essential for the maintenance of pregnancy
Pascale eGerbaud +2 more
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Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli
, 2016 Intracellular levels of the bacterial second messenger c-di-GMP are controlled by antagonistic activities of diguanylate cyclases and phosphodiesterases. The phosphodiesterase PdeH was identified as a key regulator of motility in E. coli, while deletions
Ozaki, Shogo +6 more
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Role of Phosphodiesterases in Biology and Pathology 2.0 [PDF]
Phosphodiesterases (PDEs) are ubiquitous enzymes that hydrolyse cAMP and cGMP second messengers temporally, spatially, and integratedly according to their expression and compartmentalization inside the cell [...
Mauro Giorgi +2 more
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Downstream Targets of Cyclic Nucleotides in Plants
Frontiers in Plant Science, 2018 Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska +3 more
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Characterization of horse thyroid cyclic nucleotide phosphodiesterases.
, 1980 Cyclic nucleotide phosphodiesterases have been characterized in crude soluble extract (100000 ×g supernatant) of horse thyroid. DEAE‐cellulose ion‐exchange chromatography at pH 7.4 followed by ultracentrifugation on sucrose‐density gradients separated ...
Dumont, Jacques Emile +2 more
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