Results 31 to 40 of about 17,744 (296)
Phosphodiesterases and preeclampsia
Medical Hypotheses, 2017 Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction.
Anne Brandolt, Larré +7 more
openaire +2 more sources
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
The Role of Cyclic Nucleotide Phosphodiesterases [PDF]
, 2017 A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common signaling pathway.
Vandecasteele, Grégoire +6 more
core +1 more source
Phosphodiesterase induction in Dictyostelium discoideum by inhibition of extracellular phosphodiesterase activity [PDF]
Developmental Biology, 1982 Adenosine 3’,5’-monophosphate (cAMP) is a chemoattractant in Dictyostelium discoideum; it also induces phosphodiesterase activity. Recently it was shown that N’-(aminohexyl)adenosine 3’,5’-monophosphate (hexyl-cAMP) effectively induced phosphodiesterase activity, while this compound was chemotactically inactive and did not effectively bind to the cell ...
Haastert, Peter J.M. van +2 more
openaire +3 more sources
The Phosphodiesterases in the Rat Pancreas [PDF]
European Journal of Biochemistry, 1970 The purification of two phosphodiesterases found in the rat pancreas is described. The phosphodiesterase I, an enzyme of the snake venom type, has been purified about 500 times, the phosphodiesterase II, an enzyme of the spleen type, about 60 times. The phosphodiesterase I activity, optimal at a pH of about 9.0, is completely dependent on the presence ...
W J, van Venrooij, C, Poort
openaire +2 more sources
Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
Marine Drugs, 2014 Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China.
Zhang-Hua Sun +5 more
doaj +1 more source
Epac Function and cAMP Scaffolds in the Heart and Lung
Journal of Cardiovascular Development and Disease, 2018 Evidence collected over the last ten years indicates that Epac and cAMP scaffold proteins play a critical role in integrating and transducing multiple signaling pathways at the basis of cardiac and lung physiopathology. Some of the deleterious effects of
Marion Laudette +3 more
doaj +1 more source
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina +5 more
core +1 more source
Molecules, 2016 Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).
Susann Schröder +4 more
doaj +1 more source