Results 31 to 40 of about 3,903 (78)
Toxins, 2019 (1) Background. Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes. In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysis ...
Anwar Ullah +4 more
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Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina +5 more
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PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects [PDF]
, 2015 The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent cardiac
Handschin, Christoph +5 more
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Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
Marine Drugs, 2014 Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China.
Zhang-Hua Sun +5 more
doaj +1 more source
The Role of Cyclic Nucleotide Phosphodiesterases [PDF]
, 2017 A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common signaling pathway.
Vandecasteele, Grégoire +6 more
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Epac Function and cAMP Scaffolds in the Heart and Lung
Journal of Cardiovascular Development and Disease, 2018 Evidence collected over the last ten years indicates that Epac and cAMP scaffold proteins play a critical role in integrating and transducing multiple signaling pathways at the basis of cardiac and lung physiopathology. Some of the deleterious effects of
Marion Laudette +3 more
doaj +1 more source
Molecules, 2016 Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).
Susann Schröder +4 more
doaj +1 more source
Treating chronic obstructive pulmonary disease with ensifentrine: a systematic review
Frontiers in MedicineBackgroundThe cornerstone medications for maintenance of chronic obstructive pulmonary disease (COPD) have remained the same for decades. Despite combination therapy with multiple mechanisms of action, patients with COPD have significant morbidity and ...
Sultan Almuntashiri +11 more
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BiomoleculesCyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia +11 more
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