Results 31 to 40 of about 82,227 (164)

Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. [PDF]

Appl Environ Microbiol, 2019
Pseudomonas aeruginosa is an opportunistic pathogen that can cause infections in animals, humans, and plants. The formation of biofilms by P. aeruginosa is the central mode of action to persist in hosts and evade immune and antibiotic attacks.
Wei Q, Leclercq S, Bhasme P, Xu A, Zhu B, Zhang Y, Zhang M, Wang S, Ma LZ.   +8 more
europepmc   +2 more sources

Identification of a diguanylate cyclase expressed in the presence of plants and its application for discovering candidate gene products involved in plant colonization by Pantoea sp. YR343.

PLoS ONE, 2021
Microbial colonization of plant roots is a highly complex process that requires the coordination and regulation of many gene networks, yet the identities and functions of many of these gene products have yet to be discovered. Pantoea sp.
Amber N Bible, Mang Chang, Jennifer L Morrell-Falvey   +2 more
doaj   +1 more source

Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

Nature Communications, 2021
As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely ...
Raphael D. Teixeira, Fabian Holzschuh, Tilman Schirmer   +2 more
doaj   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]

Mol Plant Pathol
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Niroula D, Bhandari K, Sundin GW, Joshi JR.   +3 more
europepmc   +2 more sources

Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response of <i>Leptospira interrogans</i> in an Ovine Dialysis Membrane Chamber Model. [PDF]

Transbound Emerg Dis
Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Dubniewicz K, Pardyak L, Walczak P, Pietsch-Fulbiszewska A, Gurgul A, Jasielczuk I, Szmatoła T, Arent ZJ.   +7 more
europepmc   +2 more sources

Identification of flgZ as a flagellar gene encoding a PilZ domain protein that regulates swimming motility and biofilm formation in Pseudomonas. [PDF]

PLoS ONE, 2014
Diguanylate cyclase and phosphodiesterase enzymatic activities control c-di-GMP levels modulating planktonic versus sessile lifestyle behavior in bacteria.
Francisco Martínez-Granero, Ana Navazo, Emma Barahona, Miguel Redondo-Nieto, Elena González de Heredia, Irene Baena, Irene Martín-Martín, Rafael Rivilla, Marta Martín   +8 more
doaj   +1 more source

Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response

Scientific Reports, 2023
Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart, Federico Sisti, Mónica C. Gestal, Julieta Fernández   +3 more
doaj   +1 more source

Engineering of Bacillus subtilis strains to allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases. [PDF]

Appl Environ Microbiol, 2014
Gao X, Dong X, Subramanian S, Matthews PM, Cooper CA, Kearns DB, Dann CE.   +6 more
europepmc   +2 more sources

Diguanylate Cyclases AdrA and STM1987 Regulate Salmonella enterica Exopolysaccharide Production during Plant Colonization in an Environment-Dependent Manner. [PDF]

Appl Environ Microbiol, 2016
Cowles KN, Willis DK, Engel TN, Jones JB, Barak JD.   +4 more
europepmc   +2 more sources

Systematic analysis of diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0-1. [PDF]

J Bacteriol, 2011
Newell PD, Yoshioka S, Hvorecny KL, Monds RD, O'Toole GA.   +4 more
europepmc   +2 more sources