Results 51 to 60 of about 82,227 (164)

Searching Hit Potential Antimicrobials in Natural Compounds Space against Biofilm Formation

Molecules, 2020
Biofilms are communities of microorganisms that can colonize biotic and abiotic surfaces and thus play a significant role in the persistence of bacterial infection and resistance to antimicrobial. About 65% and 80% of microbial and chronic infections are
Roberto Pestana-Nobles, Jorge A. Leyva-Rojas, Juvenal Yosa   +2 more
doaj   +1 more source

Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development

bioRxiv, 2020
Levels of the second messenger bis-3’-5’-cyclic di-guanosinemonophosphate (c-di-GMP) determine when Streptomyces initiate sporulation to survive under adverse conditions.
Julian Haist, S. A. Neumann, Mahmoud M. Al-Bassam, S. Lindenberg, M. Elliot, Natalia Tschowri   +5 more
semanticscholar   +1 more source

Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate

Biotechnology Reports, 2015
Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt, Dhruv P. Arora, Roger A. Johnson, Elizabeth M. Boon   +3 more
doaj   +1 more source

Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer [PDF]

, 2017
Coordination of cell movement with cell differentiation is a major feat of embryonic development. The Dictyostelium stalk always forms at the organizing tip, by a mechanism that is not understood. We previously reported that cyclic diguanylate (c-di-GMP),
Chen, Christian Cole, Christina Schilde, Early, Geoffrey J. Barton, Hajara Mohammed Lawal, Jermyn, Kay, Mann, Melanie Febrer, Pauline Schaap, Reema Singh, Robinson, Rodriguez-Centeno, Söderbom, Zhi-Hui Chen   +15 more
core   +3 more sources

Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa

MicrobiologyOpen, 2020
Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme, Qing Wei, Anming Xu, Syed Tatheer Alam Naqvi, Di Wang, Luyan Z. Ma   +5 more
doaj   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di-GMP-Specific EAL Phosphodiesterases. [PDF]

Microb Biotechnol
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Cao LY, Zhang X, Bai FW, Römling U.
europepmc   +2 more sources

High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]

, 2016
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon, Barahona, Baraquet, Berendsen, Boller, Burdette, Cao, Chinchilla, Clarke, Dangl, Dasgupta, Dong, Engl, Felix, Forsyth, Gal, Gomez-Gomez, Goymer, Guttman, Hann, Heese, Hengge, Hickman, Hickman, Jackson, Kazmierczak, Kovach, Kulasakara, Kunze, Lacombe, Lee, Li, Loon, Loper, Loper, Lugtenberg, Macho, Malone, Marino, Matilla, Miya, Newell, Nuhse, Peart, Pel, Perez-Mendoza, Plotnikova, Robleto, Rossez, Roux, Schulze, Schwessinger, Segonzac, Spangler, Starkey, Sun, Torres, Van Wees, Wang, Willmann, Winsor, Xin, Yan, Zamioudis, Zeng, Zhang, Zipfel, Zipfel, Zipfel   +68 more
core   +1 more source

Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in Dickeya zeae EC1

mBio, 2020
Dickeya zeae is an important and aggressive bacterial phytopathogen that can cause substantial economic losses in banana and rice plantations. We previously showed that c-di-GMP signaling proteins (cyclases/phosphodiesterases) in D.
Yufan Chen, Jianuan Zhou, Mingfa Lv, Zhibin Liang, Matthew R. Parsek, Lian-hui Zhang   +5 more
doaj   +1 more source

Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases [PDF]

, 2017
The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs)
A Deepthi, A Sundriyal, A Tchigvintsev, A Ueda, A Vagin, A Winkler, AD Tischler, AD Tischler, AJ Schmidt, B Huang, BW Holloway, C Chan, C Romier, CD Boyd, CW Phippen, D Balasubramanian, D Bellini, DA D’Argenio, DJ Hosfield, DL Caly, EF Pettersen, F Rao, F Rao, G Kuppuraj, G Minasov, G Winter, G Winter, GL Winsor, GN Murshudov, H Ceri, H Kulasakara, H Zheng, I Ivanov, ID Hay, J Robert-Paganin, JH Merritt, K Syson, K-H Choi, KD Miner, KM Thormann, M Christen, M Valentini, M Vorachit, MD Winn, MVAS Navarro, MY Galperin, N Barraud, O Kirillina, P Aldridge, P Emsley, P Evans, PD Newell, PR Evans, R Donlan, R Paul, R Simm, R Tamayo, RM Keegan, RP Ryan, RP Ryan, RZ Liao, TRM Barends, TT Hoang, U Römling, V Stelitano, VB Chen, W Grzybkowski, W Kabsch, Y Li, Y Qi, Y Wang   +70 more
core   +2 more sources

PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Shunsuke Kato, Koki Takeuchi, Kohei Umeda, Hisashi Kudo, Tomohisa Hasunuma, Takashi Hayashi   +5 more
wiley   +2 more sources