Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. [PDF]
Biofouling, 2014 Sambanthamoorthy K +6 more
europepmc +2 more sources
Genetic Determinants Associated With the Biofilm Formation Impairment in Pseudomonas aeruginosa Clinical Isolates. [PDF]
MicrobiologyopenNumerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Vvedenskii AV +5 more
europepmc +2 more sources
Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]
, 2019 The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R. +12 more
core +2 more sources
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]
, 2018 Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F. +8 more
core +1 more source
Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]
, 2015 UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A +2 more
core +3 more sources
A mechanistic explanation linking adaptive mutation, niche change, and fitness advantage for the Wrinkly Spreader [PDF]
, 2014 Experimental evolution studies have investigated adaptive radiation in static liquid microcosms using the environmental bacterium Pseudomonas fluorescens SBW25.
Spiers, Andrew J.
core +5 more sources
New insights into Legionella pneumophila biofilm regulation by c-di-GMP signaling [PDF]
, 2016 The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), a bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) and
Allombert, Julie +5 more
core +3 more sources
High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. [PDF]
ACS Chem Biol, 2014 Lieberman OJ, Orr MW, Wang Y, Lee VT.
europepmc +2 more sources
Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate [PDF]
, 2013 Complex 3'-5'-cyclic diguanylic acid (c-di-GMP) responsive regulatory networks that are modulated by the action of multiple diguanylate cyclases (DGC; GGDEF domain proteins) and phosphodiesterases (PDE; EAL domain proteins) have evolved in many bacteria.
Agasing, A. +3 more
core +1 more source
Presence and analysis of plasmids in human and animal associated Arcobacter species [PDF]
, 2014 In this study, we report the screening of four Arcobacter species for the presence of small and large plasmids. Plasmids were present in 9.9% of the 273 examined strains.
De Zutter, Lieven +7 more
core +8 more sources