Structural basis of activity and allosteric control of diguanylate cyclase [PDF]
Proceedings of the National Academy of Sciences, 2004 Recent discoveries suggest that a novel second messenger, bis-(3′→5′)-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by the widely distributed diguanylate cyclase (DGC or GGDEF) domain that occurs in various combinations with sensory and ...
Chan, C. +6 more
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae [PDF]
BMC Microbiology, 2012 Abstract Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections. One of the factors that contribute to virulence is its capacity to form biofilms on diverse biotic and abiotic surfaces. The second
Cruz Diana P +4 more
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Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development [PDF]
Molecular Microbiology, 2020 Abstract Levels of the second messenger bis-3’-5’-cyclic di-guanosinemonophosphate (c-di-GMP) determine when Streptomyces initiate sporulation to survive under adverse conditions. c-di-GMP signals are integrated into the genetic differentiation network by the regulator BldD and the ...
Haist, Julian +5 more
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Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle [PDF]
, 2013 Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Abel, Sören +27 more
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The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]
, 2012 The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216) +48 more
core +1 more source
Cyanobacteriochrome SesA Is a Diguanylate Cyclase That Induces Cell Aggregation in Thermosynechococcus [PDF]
Journal of Biological Chemistry, 2014 Cyanobacteria have unique photoreceptors, cyanobacteriochromes, that show diverse spectral properties to sense near-UV/visible lights. Certain cyanobacteriochromes have been shown to regulate cellular phototaxis or chromatic acclimation of photosynthetic pigments.
Gen, Enomoto +5 more
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Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia
BMC Ecology and Evolution, 2023 Abstract Background Cyclic di-guanylate (c-di-GMP), synthesized by diguanylate cyclase, is a major second messenger in prokaryotes, where it triggers biofilm formation. The dictyostelid social amoebas acquired diguanylate cyclase (dgcA) by horizontal gene transfer.
Kawabe, Yoshinori +6 more
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Searching Hit Potential Antimicrobials in Natural Compounds Space against Biofilm Formation
Molecules, 2020 Biofilms are communities of microorganisms that can colonize biotic and abiotic surfaces and thus play a significant role in the persistence of bacterial infection and resistance to antimicrobial. About 65% and 80% of microbial and chronic infections are
Roberto Pestana-Nobles +2 more
doaj +1 more source
Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR [PDF]
Journal of Molecular Biology, 2009 The bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) controls secretion, cell adhesion, and motility, leading to biofilm formation and increased cytotoxicity. Diguanylate cyclases containing GGDEF and phosphodiesterases containing EAL or HD-GYP domains have been identified as the enzymes controlling cellular c-di-
Nabanita, De +3 more
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Identification of a Diguanylate Cyclase and Its Role in Porphyromonas gingivalis Virulence [PDF]
Infection and Immunity, 2014 ABSTRACT Porphyromonas gingivalis is a Gram-negative obligate anaerobic bacterium and is considered a keystone pathogen in the initiation of periodontitis, one of the most widespread infectious diseases. Bacterial bis-(3′-5′) cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger and is involved in ...
Swarnava, Chaudhuri +5 more
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