Results 21 to 30 of about 2,135 (155)

Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization [PDF]

Journal of Biological Chemistry, 2007
Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP.
Abel, Sören, Andreas Beck, Wassmann, Paul, Sören Abel, Beck, Andreas, Ralf Paul, Heerklotz, Heiko, Jenal, Urs, Heiko Heerklotz, Urs Jenal, Paul Wassmann, Paul, Ralf   +11 more
core   +5 more sources

The thermosensory diguanylate cyclase (tdcA)

, 2016
Biofilm production in Pseudomonas aeruginosa is regulated by the intracellular secondary messenger cyclic diguanylate (c-di-GMP). C-di-GMP is produced by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs).
Randall, Trevor Ethan
core   +3 more sources

Cooperative substrate binding by a diguanylate cyclase

Journal of Molecular Biology, 2021
XAC0610, from Xanthomonas citri subsp. citri, is a large multi-domain protein containing one GAF (cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA) domain, four PAS (Per-Arnt-Sim) domains and one GGDEF domain.
Oliveira, Maycon C., Andrade, Maxuel O., Teixeira, Raphael D., Pinheiro, Glaucia M. S., Ramos, Carlos H. I., Farah, Chuck S.   +5 more
core   +4 more sources

Characterization of Mycobacterium leprae diguanylate cyclases [PDF]

, 2016
Includes bibliographical references.2016 Summer.Mycobacterium leprae is the causative agent of leprosy, which is still a major health problem in several developing countries.
Brennan, Patrick J., committee member, Borlee, Brad R., committee member, Rotcheewaphan, Suwatchareeporn, author, Prenni, Jessica E., committee member, Belisle, John T., advisor, Jackson, Mary, committee member   +5 more
core   +2 more sources

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila

mBio, 2011
Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence.
Assaf Levi, Marc Folcher, Urs Jenal, Howard A. Shuman   +3 more
doaj   +2 more sources

Flavonoids interfere with biofilm formation by targeting diguanylate cyclases in multidrug resistant Vibrio cholerae [PDF]

Scientific Reports
Rise of antibiotic resistance has led to increased treatment failures in severe cholera cases across the globe. The etiological agent Vibrio cholerae is known for its ability to persist in human gut and environmental settings through biofilm formation ...
Tuhin Manna, Subhamoy Dey, Monalisha Karmakar, Debarati Jana, Kartik Chandra Guchhait, Subrata Hazra, Saroj Ballav, Samaresh Paria, Fernando Berton Zanchi, Maidul Hossain, Amiya Kumar Panda, Chandradipa Ghosh   +11 more
doaj   +2 more sources

Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa [PDF]

MicrobiologyOpen, 2020
Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme, Qing Wei, Anming Xu, Syed Tatheer Alam Naqvi, Di Wang, Luyan Z. Ma   +5 more
doaj   +3 more sources

Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria [PDF]

mBio
Diguanylate cyclases (DGCs) synthesize bis-(3′,5′)-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes.
Xuan Lai, Manda Yu, Chiu-Ping Cheng, Erh-Min Lai   +3 more
doaj   +2 more sources

Structural studies of the periplasmic portion of the diguanylate cyclase CdgH from Vibrio cholerae

Scientific Reports, 2017
Cyclic diguanylate monophosphate (c-di-GMP) is a second messenger involved in bacterial signal transduction and produced by diguanylate cyclases (DGCs) generally containing highly variable periplasmic signal-recognition domains. CdgH is a DGC enzyme that
Min Xu, Yi-Zhi Wang, Xiu-An Yang, Tao Jiang, Wei Xie   +4 more
doaj   +2 more sources

Investigations on genomic, topological and structural properties of diguanylate cyclases involved in Vibrio cholerae biofilm signalling using in silico techniques: Promising drug targets in combating cholera

Current Research in Structural Biology
During various stages of its life cycle, Vibrio cholerae initiate biofilm signalling cascade. Intercellular high level of the signalling nucleotide 3′-5′ cyclic dimeric guanosine monophosphate (c-di-GMP), synthesized by diguanylate cyclases (DGCs) from ...
Tuhin Manna, Subhamoy Dey, Monalisha Karmakar   +2 more
exaly   +3 more sources