Shigella flexneri Diguanylate Cyclases Regulate Virulence. [PDF]
J Bacteriol, 2021 The intracellular human pathogen Shigella causes dysentery, resulting in as many as one million deaths per year. Currently, there is no approved vaccine for the prevention of shigellosis, and the incidence of antimicrobial resistance among Shigella ...
Ojha R +3 more
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Correction for Li et al., "Global Transcriptional Repression of Diguanylate Cyclases by MucR1 Is Essential for Sinorhizobium-Soybean Symbiosis". [PDF]
mBio, 2021 Volume 12, issue 5, e01192-21, 2021, https://doi.org/10.1128/mBio.01192-21. In Fig. 2B of the original paper, the image of the Western blot that shows the expression level of c15850 using anti-His monoclonal antibody was duplicated in the panel for ...
Li ML +5 more
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A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]
Frontiers in ChemistryCyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li +4 more
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Intact and mutated Shigella diguanylate cyclases increase c-di-GMP. [PDF]
J Biol ChemThe intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine.
Ojha R, Krug S, Jones P, Koestler BJ.
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Phytopathology ResearchKiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang +7 more
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π-Helix controls activity of oxygen-sensing diguanylate cyclases. [PDF]
Biosci Rep, 2020 The ability of organisms to sense and adapt to oxygen levels in their environment leads to changes in cellular phenotypes, including biofilm formation and virulence.
Walker JA, Wu Y, Potter JR, Weinert EE.
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A fluorescence-based high-throughput screening method for determining the activity of diguanylate cyclases and c-di-GMP phosphodiesterases. [PDF]
RSC Adv, 2020 The dinucleotide 3′,5′-cyclic diguanylic acid (c-di-GMP) is a critical second messenger found in bacteria. High cellular levels of c-di-GMP are associated with a sessile, biofilm lifestyle in many bacteria, which is associated with more than 70% of ...
Wang ZQ, Xuan TF, Liu J, Chen WM, Lin J.
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Coiled-coil register transitions and coupling with the effector's inhibitory site enables high fold changes in blue light-regulated diguanylate cyclases. [PDF]
J Biol ChemCellular signaling cascades rely on transfer of information from one protein to another or within a single protein. To facilitate signal integration, specific structural motifs evolved that allow signal processing and also enable modular downstream ...
Vide U +3 more
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Correction for Zamorano-Sánchez et al., "Functional Specialization in Vibrio cholerae Diguanylate Cyclases: Distinct Modes of Motility Suppression and c-di-GMP Production". [PDF]
mBio, 2020 Volume 10, no. 2, e00670-19, 2019. [https://doi.org/10.1128/mBio.00670-19][1]. On PDF page 7, the last line from the last paragraph reads “by three c-di-GMP riboswitches (Bc3 to Bc5) arrayed in tandem.” It should read “by two c-di-GMP riboswitches from ...
Zamorano-Sánchez D +7 more
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A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling
Annual Review of Microbiology, 2017 George A O'toole
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