Biotechnology Reports, 2015 Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt +3 more
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Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase [PDF]
Nature Communications, 2021 As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely ...
Raphael D. Teixeira +2 more
doaj +7 more sources
Phosphorylation-independent regulation of the diguanylate cyclase WspR.
PLoS Biology, 2008 Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger.
Nabanita De +5 more
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Specific Control of
mBio, 2010 The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt +7 more
doaj +3 more sources
c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases. [PDF]
PLoS Genetics, 2011 Clostridium difficile infections have become a major healthcare concern in the last decade during which the emergence of new strains has underscored this bacterium's capacity to cause persistent epidemics.
Eric Bordeleau +3 more
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Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy [PDF]
Nucleic Acids Research, 2013 Bacteria react to adverse environmental stimuli by clustering into organized communities called biofilms. A remarkably sophisticated control system based on the dinucleotide 3′–5′ cyclic diguanylic acid (c-di-GMP) is involved in deciding whether to form ...
Stefano Franceschini +2 more
exaly +4 more sources
Structure and signaling mechanism of a zinc-sensory diguanylate cyclase [PDF]
Structure, 2013 Diguanylate cyclases synthesize the second messenger c-di-GMP, which in turn governs a plethora of physiological processes in bacteria. Although most diguanylate cyclases harbor sensory domains, their input signals are largely unknown.
Zähringer, Franziska +4 more
core +7 more sources
Intact and mutated Shigella diguanylate cyclases increase c-di-GMP [PDF]
Journal of Biological ChemistryThe intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling ...
Stefanie Krug, Benjamin J Koestler
exaly +4 more sources
Systematic Analysis of Diguanylate Cyclases That Promote Biofilm Formation by Pseudomonas fluorescens Pf0-1 [PDF]
Journal of Bacteriology, 2011 Cyclic di-GMP (c-di-GMP) is a broadly conserved, intracellular second-messenger molecule that regulates biofilm formation by many bacteria. The synthesis of c-di-GMP is catalyzed by diguanylate cyclases (DGCs) containing the GGDEF domain, while its ...
Shiro Yoshioka, George A O´Toole
exaly +4 more sources
Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response [PDF]
Scientific Reports, 2023 Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart +3 more
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