Results 71 to 80 of about 2,135 (155)

A GGDEF and EAL domain-containing protein in Pseudomonas syringae pv. actinidiae regulates virulence via its diguanylate cyclase activity

Phytopathology Research
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang, Mingming Yang, Jinfang Zhou, Xianwei Xie, Jiabing Ma, Yao Wang, Xihui Shen, Lili Huang   +7 more
doaj   +1 more source

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
doaj   +1 more source

Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus

Frontiers in Microbiology, 2018
The bacterial second messenger cyclic diguanylate monophosphate (c-di-GMP) regulates a series of cellular functions, including biofilm formation, motility, virulence, and other processes.
Jiahui He, Jiahui He, Jiahui He, Wenhao Ruan, Jieli Sun, Fang Wang, Wenjuan Yan   +6 more
doaj   +1 more source

RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. [PDF]

PLoS ONE, 2012
Biofilm formation and dispersal in the black rot pathogen Xanthomonas campestris pathovar campestris (Xcc) is influenced by a number of factors. The extracellular mannanase ManA has been implicated in biofilm dispersal whereas biofilm formation requires ...
Xiu-Hong Lu, Shi-Qi An, Dong-Jie Tang, Yvonne McCarthy, Ji-Liang Tang, John Maxwell Dow, Robert P Ryan   +6 more
doaj   +1 more source

Identification of Anti-Inflammatory and Anti-Hypertensive Drugs as Inhibitors of Bacterial Diguanylate Cyclases

, 2018
Biofilms are widely present in many human chronic infections, often more resistant to treatment with antibiotics. Bacterial diguanylate cyclases (DGCs) synthesize cyclic dimeric guanosine monophosphate (c-di-GMP) from two guanosine-5'-triphosphate (GTP ...
Juliana Cheleski (449504), Éverton E. D. Silva (4868119), Helton J. Wiggers (449499), Edson Crusca (4640815), Naiara U. Torres (4868122), Marcos V. A. S. Navarro (231597)   +5 more
core   +1 more source

In vivo Analysis of Cyclic di-GMP Cyclase and Phosphodiesterase Activity in Escherichia coli Using a Vc2 Riboswitch-based Assay

Bio-Protocol, 2018
Cyclic di-guanosine monophosphate (c-di-GMP) is a ubiquitous second messenger that regulates distinct aspects of bacterial physiology. It is synthesized by diguanylate cyclases (DGCs) and hydrolyzed by phosphodiesterases (PDEs).
Ying Liu, Hyunhee Kim, Ute Römling
doaj   +1 more source

Analysis of CdgC as the major diguanylate cyclase in S. venezuelae

, 2021
The proliferation of Gram-positive soil bacteria Streptomyces is temporally and genetically coordinated with a complex developmental life cycle, including three main stages of differentiation: vegetative hyphal growth, formation of aerial mycelium and sporulation.
openaire   +1 more source

Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c

Microbiology, 2016
The second messenger, bis-(3',5')-cyclic dimeric guanosine monophosphate (cyclic di-GMP), is involved in the control of multiple bacterial phenotypes, including those that impact host-pathogen interactions. Bioinformatics analyses predicted that Mycobacterium leprae, an obligate intracellular bacterium and the causative agent of leprosy, encodes three ...
Suwatchareeporn, Rotcheewaphan, John T, Belisle, Kristofor J, Webb, Hee-Jin, Kim, John S, Spencer, Bradley R, Borlee   +5 more
openaire   +2 more sources

C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation [PDF]

, 2016
Cellular levels of the second messenger cyclic di-guanosine monophosphate (c-di-GMP) are determined by the antagonistic activities of diguanylate cyclases and specific phosphodiesterases.
Schirmer, Tilman
core   +1 more source

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence

, 2019
The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections in immunocompromised individuals and chronic respiratory disease in patients with cystic fibrosis.
Kulesekara, Hemantha, Lee, Daniel, Brencic, Anja, Liberati, Nicole, Miyata, Sachiko, Neely, Alice, Hyodo, Mamoru, Lee, Vincent, Urbach, Jonathan, Hayakawa, Yoshihiro, Lory, Stephen, Ausubel, Frederick   +11 more
core   +1 more source