Results 81 to 90 of about 2,135 (155)

Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus.

PLoS Pathogens
Vibrio species, which include several pathogens, are autochthonous to estuarine and warm coastal marine environments, where biofilm formation bolsters their ecological persistence and transmission.
Shobnom Mustaree, Ram Podicheti, Doug Rusch, Dean A Rowe-Magnus   +3 more
doaj   +1 more source

Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector

mBio, 2015
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger that controls multiple cellular processes. c-di-GMP networks have up to dozens of diguanylate cyclases (DGCs) that synthesize c-di-GMP along with many c-di-GMP-responsive target proteins that ...
Kurt M. Dahlstrom, Krista M. Giglio, Alan J. Collins, Holger Sondermann, George A. O’Toole   +4 more
doaj   +1 more source

Elucidation of the regulatory mechanisms of the diguanylate cyclases PleD, DgcA and DgcB by structural and biophysical analysis [PDF]

, 2009
The ubiquitous bacterial second messenger bis-(3’-5’)-cycic di-guanosine monophosphate (c-di-GMP) turns out to be the key regulator of the antagonistic processes: motility of individual cells on the one hand and persistence of a bacterial population in ...
Wassmann, Paul
core   +1 more source

Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases. [PDF]

Sci Adv, 2023
Vide U, Kasapović D, Fuchs M, Heimböck MP, Totaro MG, Zenzmaier E, Winkler A.   +6 more
europepmc   +1 more source

c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa

mSphere
The universal bacterial second messenger bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence.
Qishun Feng, Xin Dai, Qiulan Wu, Lianhui Zhang, Liang Yang, Yang Fu   +5 more
doaj   +1 more source

Characterisation of sequence-structure-function space in sensor-effector integrators of phytochrome-regulated diguanylate cyclases. [PDF]

Photochem Photobiol Sci, 2022
Böhm C, Gourinchas G, Zweytick S, Hujdur E, Reiter M, Trstenjak S, Sensen CW, Winkler A.   +7 more
europepmc   +1 more source

The Impact of Oxygen Availability and Oxidative Stress on Regulation of Cyclic-dimeric-GMP in Listeria monocytogenes strain F2365

, 2021
Listeria monocytogenes is a gram-positive foodborne pathogen that results in the infectious disease listeriosis. The second messenger molecule cyclic-dimeric-GMP has been found to be responsible for the regulation of expression of many of its virulence ...
Welch, Anna G
core  

More than Enzymes That Make or Break Cyclic Di-GMP—Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli

mBio, 2017
The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains)
Olga Sarenko, Gisela Klauck, Franziska M. Wilke, Vanessa Pfiffer, Anja M. Richter, Susanne Herbst, Volkhard Kaever, Regine Hengge   +7 more
doaj   +1 more source

Identification of an interaction between diguanylate cyclase CdgB and a putative interacting partner (PIP) in Streptomyces

Streptomyces is a group of filamentous bacteria, best known to produce diverse clinically important antibiotics. This group has a complex life cycle regulated by 3’-5’-cyclic diguanylic acid (c-diGMP).
Prada Mora, Juanita
core   +1 more source

A general mechanism for initiating the bacterial general stress response

eLife
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. The serine/threonine phosphatase RsbU initiates the General Stress Response
Rishika Baral, Kristin Ho, Ramasamy P Kumar, Jesse B Hopkins, Maxwell B Watkins, Salvatore LaRussa, Suhaily Caban-Penix, Logan A Calderone, Niels Bradshaw   +8 more
doaj   +1 more source