Results 1 to 10 of about 7,255 (192)

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B.
Elizabeth A. Novak, Syed Z. Sultan, Md. A. Motaleb   +2 more
doaj   +4 more sources

Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. [PDF]

PLoS Genetics, 2013
Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Sören Abel, Tabitha Bucher, Micaël Nicollier, Isabelle Hug, Volkhard Kaever, Pia Abel Zur Wiesch, Urs Jenal   +6 more
doaj   +1 more source

Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. [PDF]

PLoS Pathogens, 2012
The second messenger, cyclic diguanylate (c-di-GMP), regulates diverse cellular processes in bacteria. C-di-GMP is produced by diguanylate cyclases (DGCs), degraded by phosphodiesterases (PDEs), and receptors couple c-di-GMP production to cellular ...
Nicholas J Shikuma, Jiunn C N Fong, Fitnat H Yildiz   +2 more
doaj   +1 more source

High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization

mBio, 2022
During colonization of the Hawaiian bobtail squid (Euprymna scolopes), Vibrio fischeri bacteria undergo a lifestyle transition from a planktonic motile state in the environment to a biofilm state in host mucus.
Ruth Y. Isenberg, David G. Christensen, Karen L. Visick, Mark J. Mandel   +3 more
doaj   +1 more source

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems. [PDF]

PLoS Pathogens, 2015
Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins.
Kevin G Roelofs, Christopher J Jones, Sarah R Helman, Xiaoran Shang, Mona W Orr, Jonathan R Goodson, Michael Y Galperin, Fitnat H Yildiz, Vincent T Lee   +8 more
doaj   +1 more source

Quorum-Sensing Master Regulator VfmE Is a c-di-GMP Effector That Controls Pectate Lyase Production in the Phytopathogen Dickeya dadantii

Microbiology Spectrum, 2022
Dickeya dadantii is a phytopathogenic bacterium that causes diseases on a wide range of host plants. The pathogen secretes pectate lyases (Pel) through the type II secretion system (T2SS) that degrades the cell wall in host plants.
Biswarup Banerjee, Quan Zeng, Manda Yu, Brian Y. Hsueh, Christopher M. Waters, Ching-Hong Yang   +5 more
doaj   +1 more source

c-di-GMP Inhibits Early Sporulation in Clostridioides difficile

mSphere, 2021
The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo   +4 more
doaj   +1 more source

Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens

mSystems, 2022
Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
doaj   +1 more source

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus [PDF]

, 2016
Generally, the second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
A Duerig, A Konovalova, A Lu, AJ Schmidt, B Julien, BK Bharati, BY Chang, BY Matsuyama, BZ Harris, C Baraquet, C Spangler, CD Boyd, D Amikam, D Kaiser, D Skotnicka, D Srivastava, DA Ryjenkov, DA Ryjenkov, Dorota Skotnicka, E Bordeleau, E Trampari, Eleftheria Trampari, Gregory T. Smaldone, H Lancero, I Bulyha, I Letunic, IS Pultz, J Hodgkin, J Hodgkin, J Sambrook, Jacob G. Malone, Jennifer Liang, JJ Wilksch, Josep Casadesús, JP Massie, JT Pratt, JW Hickman, JW Hickman, KG Roelofs, KH Chin, L Hobley, L Jelsbak, L Søgaard-Andersen, LJ Shimkets, Lotte Søgaard-Andersen, M Christen, M Christen, M Fazli, M Merighi, M Overgaard, M Singer, Mitchell Singer, MR Neunuebel, MV Navarro, N Sudarsan, N Tschowri, NB Caberoy, PD Newell, PV Krasteva, PV Krasteva, R Hengge, R Paul, R Paul, R Tamayo, RP Ryan, RP Ryan, RP Ryan, S Abel, S Steiner, SS Wu, SS Wu, SS Wu, SZ Sultan, T Petters, T Schirmer, TA Ramelot, TM Gronewold, Tobias Petters, U Römling, V Jakovljevic, Volkhard Kaever, W Li, X Fang, Y Li, Y Qi, Z Yang, ZH Chen, ZM Yang   +87 more
core   +6 more sources

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Scientific Reports, 2023
Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence.
Badri Nath Dubey, Viktoriya Shyp, Geoffrey Fucile, Holger Sondermann, Urs Jenal, Tilman Schirmer   +5 more
doaj   +1 more source