High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]
, 2018 The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A +2 more
core +2 more sources
A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins
Bio-Protocol, 2015 Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many processes in bacteria including biofilm formation, motility, and virulence (Hengge, 2009). Analysis of c-di-GMP binding properties of bacterial proteins is an important step to
Disha Srivastava, Christopher Waters
doaj +1 more source
Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]
, 2019 The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R. +12 more
core +2 more sources
BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation [PDF]
, 2017 The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Cecéília M. Arraiano +7 more
core +5 more sources
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]
, 2016 Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch ...
Dubey, Badri N. +6 more
core +2 more sources
mSphere, 2018 The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles.
Robert W. McKee +2 more
doaj +1 more source
Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in
mBio, 2020 Dickeya zeae is an important and aggressive bacterial phytopathogen that can cause substantial economic losses in banana and rice plantations. We previously showed that c-di-GMP signaling proteins (cyclases/phosphodiesterases) in D.
Yufan Chen +5 more
doaj +1 more source
Microbiology Spectrum, 2023 Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee +2 more
doaj +1 more source
Roles of the second messenger cyclic di-GMP in environmental adaptation of Sinorhizobium meliloti [PDF]
, 2017 Bacteria have evolved various systems for the integration of environmental signals to rapidly coordinate cellular pathways and adapt to changes in their environment.
Schäper, Simon
core +1 more source
Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch
Molecules, 2012 C-di-GMP, a cyclic guanine dinucleotide, has been shown to regulate biofilm formation as well as virulence gene expression in a variety of bacteria. Analogues of c-di-GMP have the potential to be used as chemical probes to study c-di-GMP signaling and ...
Herman O. Sintim +4 more
doaj +1 more source