Progress in understanding of the molecular basis underlying functional diversification of cyclic di-nucleotide turnover proteins [PDF]
, 2016 Cyclic di-GMP was the first cyclic di-nucleotide second messenger described, presaging the discovery of additional cyclic di-nucleotide messengers in bacteria and eukaryotes.
Dow, J. Maxwell +2 more
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Role of small colony variants in persistence of Pseudomonas aeruginosa infections in cystic fibrosis lungs [PDF]
, 2015 Jacob G Malone1,21John Innes Centre, Norwich, UK; 2School of Biological Sciences, University of East Anglia, Norwich, UKAbstract: Pseudomonas aeruginosa is an opportunistic pathogen that predominates during the later stages of cystic fibrosis (CF) lung ...
Malone, Jacob
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Nitric oxide regulated cyclic di-GMP signaling [PDF]
BMC Pharmacology and Toxicology, 2013 Background Nitric oxide (NO), a well-known signaling molecule in eukaryotic organisms, has recently been implicated in the development of bacterial biofilms. Biofilms are surfacebound, matrix-encapsulated, multicellular communities that are extremely resistant to antibiotic treatments.
Boon, Elizabeth M +5 more
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Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa [PDF]
Cell Reports, 2022 Bacteria in biofilms are embedded in extracellular matrix and display low metabolic activity, partly due to insufficient diffusive exchange of metabolic substrate. The extracellular matrix and low metabolic activity both contribute to the high antibiotic tolerance-the hallmark of biofilm bacteria.
Mads Lichtenberg +5 more
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eLife, 2014 Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments.
Debashree Chatterjee +5 more
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A mechanistic explanation linking adaptive mutation, niche change, and fitness advantage for the Wrinkly Spreader [PDF]
, 2014 Experimental evolution studies have investigated adaptive radiation in static liquid microcosms using the environmental bacterium Pseudomonas fluorescens SBW25.
Spiers, Andrew J.
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RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. [PDF]
PLoS ONE, 2012 Biofilm formation and dispersal in the black rot pathogen Xanthomonas campestris pathovar campestris (Xcc) is influenced by a number of factors. The extracellular mannanase ManA has been implicated in biofilm dispersal whereas biofilm formation requires ...
Xiu-Hong Lu +6 more
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Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming
mBio, 2022 Bacterial motility has great medical and ecological significance because of its essential role in bacterial survival and pathogenesis. Cyclic dimeric GMP (c-di-GMP), a second messenger in bacteria, is the predominant regulator of flagellar synthesis and ...
Xin Zhang +7 more
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Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]
, 2015 The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel +89 more
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High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]
, 2018 The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A +2 more
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