Allosteric control of cyclic di-GMP signaling [PDF]
Journal of Biological Chemistry, 2006 Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host.
Christen, B. +7 more
core +6 more sources
Controlling Biofilm Development Through Cyclic di-GMP Signaling. [PDF]
Adv Exp Med Biol, 2022 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date summary of c-di-GMP pathways connected to biofilm formation by the opportunistic pathogen P ...
Park S, Sauer K.
europepmc +3 more sources
High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization
mBio, 2022 During colonization of the Hawaiian bobtail squid (Euprymna scolopes), Vibrio fischeri bacteria undergo a lifestyle transition from a planktonic motile state in the environment to a biofilm state in host mucus.
Ruth Y. Isenberg +3 more
doaj +1 more source
Switching on cyclic di-GMP heterogeneity in Pseudomonas aeruginosa biofilms. [PDF]
Nat Microbiol, 2023 Gomez JB, Waters CM.
europepmc +3 more sources
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic +83 more
core +12 more sources
Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
Pathogens, 2020 Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosphate (c-di-AMP),
Samira Elmanfi +5 more
doaj +1 more source
Nucleotides as Bacterial Second Messengers
Molecules, 2023 In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz +3 more
doaj +1 more source
Detection of Cyclic di-GMP Binding Proteins Utilizing a Biotinylated Cyclic di-GMP Pull-Down Assay [PDF]
, 2017 Cyclic di-GMP is an important regulatory messenger molecule that often directly interacts with proteins to alter function. It is therefore important to find potential c-di-GMP binding proteins and verify a direct interaction between them. Here, we describe a pull-down assay using biotinylated-c-di-GMP to capture a specific protein of interest followed ...
Jacob R, Chambers, Karin, Sauer
openaire +2 more sources
High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]
, 2016 The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon +68 more
core +1 more source
Frontiers in Microbiology, 2014 We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev +10 more
doaj +1 more source