Results 11 to 20 of about 38,088 (227)

Beta Testing New Roles of Cyclic Guanosine Monophosphate in Cardiac Myocyte Contractility [PDF]

JACC: Basic to Translational Science
Robert M. Blanton, MA, MD
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Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications

Molecules, 2021
For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
doaj   +1 more source

Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes

JACC: Basic to Translational Science, 2023
Summary: Reduced nitric oxide (NO) bioactivity in red blood cells (RBCs) is critical for augmented myocardial ischemia-reperfusion injury in type 2 diabetes.
Tong Jiao, MD, PhD, Aida Collado, PhD, Ali Mahdi, MD, PhD, John Tengbom, MD, Yahor Tratsiakovich, MD, PhD, G. Todd Milne, PhD, Michael Alvarsson, MD, PhD, Jon O. Lundberg, MD, PhD, Zhichao Zhou, MD, PhD, Jiangning Yang, MD, PhD, John Pernow, MD, PhD   +10 more
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Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

Frontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun, Alejandra Recalde, Heike Bähre, Roland Seifert, Sonja-Verena Albers   +4 more
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A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Nature Communications, 2021
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair ...
Daipayan Banerjee, Kurt Langberg, Salar Abbas, Eric Odermatt, Praveen Yerramothu, Martin Volaric, Matthew A. Reidenbach, Kathy J. Krentz, C. Dustin Rubinstein, David L. Brautigan, Tarek Abbas, Bradley D. Gelfand, Jayakrishna Ambati, Nagaraj Kerur   +13 more
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Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

iScience, 2023
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet.
Judit E. Šponer, Jiří Šponer, Jakub Výravský, Roman Matyášek, Aleš Kovařík, Wojciech Dudziak, Katarzyna Ślepokura   +6 more
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Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging

Communications Biology, 2022
A red fluorescent protein-based indicator of cyclic guanosine 3′, 5′-monophosphate (cGMP) allows for multi-colour imaging and optogenetic applications while monitoring cGMP activity in cells.
Mai Takizawa, Yuri Osuga, Rika Ishida, Marie Mita, Kazuki Harada, Hiroshi Ueda, Tetsuya Kitaguchi, Takashi Tsuboi   +7 more
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Vericiguat: A New Hope for Heart Failure Patients

Cardiovascular Therapeutics, 2022
Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse vital tissues.
Raquel Chiles, Rami A. Al-Horani
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The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Frontiers in Pharmacology, 2022
Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad, Kaisun Nesa Lesa, Ari Sudarmanto, Nanang Fakhrudin, Nanang Fakhrudin, Zullies Ikawati   +5 more
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Effect of cyclic 
guanosine‐monophosphate on porcine retinal vasomotion [PDF]

Acta Ophthalmologica Scandinavica, 2006
Abstract.Purpose:  Vasomotion refers to periodic oscillations in vascular tone that ensure the intermittent supply of blood to adjacent microvascular units. Previous evidence from vessels outside the eye suggests that cyclic guanosine‐monophosphate (cGMP) is involved in the regulation of vasomotion, but it is unknown whether this compound has an ...
Anders, Hessellund, Christian, Aalkjaer, Toke, Bek   +2 more
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