Results 161 to 170 of about 90,964 (311)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Behavior of FRP-Concrete Beam-Columns under Cyclic Loading

, 2003
Use of concrete-filled fiber-reinforced polymers (FRP) tubes (CFFT) for columns and piles has been studied extensively over the last decade. The focus, however, has been exclusively on the monotonic behavior of CFFT.
Shao, Yutian
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evaluation of the Self-Healing Capacity of Asphalt Concrete with Polymer Capsules Containing Rejuvenator Under Various Cyclic Load Conditions. [PDF]

Materials (Basel)
Wan P, Ma Z, Lin Z, Zhong P, Zou X, Shen Y, Lin N, Chen H, Wang J, Wu S, Liu Q, Zhang L, Gong X.   +12 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Dual-Triggered Release Mechanisms in Calcium Alginate/Fe₃O₄ Capsules for Asphalt Self-Healing: Cyclic Load-Induced Sustained Release and Microwave-Activated On-Demand Delivery. [PDF]

Polymers (Basel)
Wan P, Wang J, Ma Z, Lin Z, Zhong P, Zou X, Shen Y, Lin N, Chen H, Wu S, Liu Q, Feng J, Zhang L, Gong X.   +13 more
europepmc   +1 more source

Modeling of overloads in cyclic loading

, 2022
While researchers have tried to predict mechanical response in cyclic loading, the mod- elling of overloads (monotonic loads among cycles) is still missing in the literature. This work presents a new crystal plasticity approach to predict the overload response.
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Influence of the Timing of Cyclic Load Application on Cardiac Cell Contraction. [PDF]

Front Physiol, 2018
Debbi L, Drori S, Tzlil S.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source