Results 261 to 270 of about 86,821 (289)

Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase

Drug Metabolism and Disposition, 2007
[7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) is a novel multi-targeted Src family kinase inhibitor with demonstrated anticancer activity in preclinical species. Potent kinase inhibition is associated with TG100435 and its major N-oxide metabolite [7-(2,6-dichlorophenyl)-5-methyl ...
Ahmed, Kousba, Richard, Soll, Shiyin, Yee, Michael, Martin   +3 more
openaire   +2 more sources

Model iron-catalyzed biomimetic cyclization of a cyclic tryptamine N-oxide

The Journal of Organic Chemistry, 1972
C A, Scherer, C A, Dorschel, J M, Cook, P W, Le Quesne   +3 more
openaire   +2 more sources

Strained Cyclic Acetylenes, VII. Addition of Sulfur and Pyridine-N-oxide to Seven Membered Cycloalkynes

HETEROCYCLES, 1979
Adolf Krebs, Horst Colberg, Ulrich Höpfner, Horst Kimling, Johannes Odenthal   +4 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Palladium‐Catalyzed Coupling Reactions of Thioimidate N‐Oxides: Access to α‐Alkenyl‐ and α‐Aryl‐Functionalized Cyclic Nitrones

Angewandte Chemie International Edition, 2010
Julie, Schleiss, Patrick, Rollin, Arnaud, Tatibouët   +2 more
openaire   +2 more sources

Access to tetrahydrophenanthridine N-oxides via Rh(III)-catalyzed cascade C–H activation/cyclization of cyclic 2-diazo-1,3-diones and aryloximes

Tetrahedron, 2023
Yinyin Feng, Guanghao Shi, Liwei Xiang, Wangcheng Hu, Xinwei He, Yongjia Shang   +5 more
openaire   +1 more source

Photoelectron spectra of cyclic azo N-oxides and azo N,N'-dioxides

The Journal of Organic Chemistry, 1977
openaire   +1 more source

ChemInform Abstract: PHOTOELECTRON SPECTRA OF CYCLIC AZO N‐OXIDES AND AZO N,N′‐DIOXIDES

Chemischer Informationsdienst, 1977
openaire   +1 more source

Analogs of Aspergillic Acid. IV. Substituted 2-Bromopyridine-N-oxides and Their Conversion to Cyclic Thiohydroxamic Acids¹

Journal of the American Chemical Society, 1950
Elliott Shaw, Jack Bernstein, Kathryn Losee, W. A. Lott   +3 more
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly