Results 1 to 10 of about 1,368,358 (400)

Cyclic nucleotide signalling in malaria parasites [PDF]

Open Biology, 2017
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
David A. Baker, Laura G. Drought, Christian Flueck, Stephanie D. Nofal, Avnish Patel, Maria Penzo, Eloise M. Walker   +6 more
doaj   +5 more sources

Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential [PDF]

mBio
Apicomplexa encompasses a large number of intracellular parasites infecting a wide range of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and cellular processes.
William J. Moss, Lorenzo Brusini, Ronja Kuehnel, Mathieu Brochet, Kevin M. Brown   +4 more
doaj   +2 more sources

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

Nature Communications, 2018
Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction, but conformational changes associated with gating remained unknown.
Arin Marchesi, Xiaolong Gao, Ricardo Adaixo, Jan Rheinberger, Henning Stahlberg, Crina Nimigean, Simon Scheuring   +6 more
doaj   +2 more sources

Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling

Frontiers in Plant Science, 2017
The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and ...
Chris Gehring, Chris Gehring, Ilona S. Turek, Ilona S. Turek   +3 more
doaj   +2 more sources

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

Nature Reviews Drug Discovery, 2019
Gonzalo S Tejeda, Michy P Kelly, George S Baillie   +2 more
exaly   +2 more sources

Advances in targeting cyclic nucleotide phosphodiesterases

Nature Reviews Drug Discovery, 2014
Hengming Ke, Faiyaz Ahmad Khan, Yousheng Wang   +2 more
exaly   +2 more sources

Cyclic nucleotide-induced helical structure activates a TIR immune effector

Nature, 2022
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins.
Gaëlle Hogrel, Abbie Guild, S. Graham, Hannah Rickman, S. Grüschow, Quentin Bertrand, L. Spagnolo, M. F. White   +7 more
semanticscholar   +1 more source

Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense.

Annual Review of Virology, 2022
Advances in our understanding of prokaryotic antiphage defense mechanisms in the past few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a crucial role in switching infected cells into an antiviral state.
Januka S. Athukoralage, M. F. White
semanticscholar   +1 more source

The Complex Story of Plant Cyclic Nucleotide-Gated Channels

International Journal of Molecular Sciences, 2021
Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP).
Edwin Jarratt-Barnham, Limin Wang, Youzheng Ning, J. Davies   +3 more
semanticscholar   +1 more source

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

Frontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun, Alejandra Recalde, Heike Bähre, Roland Seifert, Sonja-Verena Albers   +4 more
doaj   +1 more source