Cyclic nucleotide signalling in malaria parasites [PDF]
Open Biology, 2017 The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
David A. Baker +6 more
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Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential [PDF]
mBioApicomplexa encompasses a large number of intracellular parasites infecting a wide range of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and cellular processes.
William J. Moss +4 more
doaj +2 more sources
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel. [PDF]
Nat Struct Mol Biol, 2023 Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cyclic nucleotide-modulated and cyclic nucleotide-gated channels, especially at the level of the cyclic nucleotide ...
Pan Y +6 more
europepmc +5 more sources
Editorial: Cyclic nucleotide phosphodiesterases (PDEs) signaling in the endocrine system. [PDF]
Front Endocrinol (Lausanne)Campolo F, Samidurai A.
europepmc +3 more sources
Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A. [PDF]
J Biol ChemZemskov EA +9 more
europepmc +3 more sources
Frontiers in Microbiology, 2021 Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun +4 more
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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. [PDF]
PLoS ONE, 2011 Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation.
Jeong Joo Kim +10 more
doaj +1 more source
Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. [PDF]
PLoS ONE, 2017 Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding domain (CNBD) in their C-terminal region linked to the pore-forming transmembrane segment with
Sebastien Hayoz +4 more
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Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels. [PDF]
PLoS ONE, 2015 Cyclic nucleotide-sensitive ion channels are molecular pores that open in response to cAMP or cGMP, which are universal second messengers. Binding of a cyclic nucleotide to the carboxyterminal cyclic nucleotide binding domain (CNBD) of these channels is ...
Divya Kesters +8 more
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