Results 61 to 70 of about 1,368,358 (400)
CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones
Frontiers in Molecular Biosciences, 2021 The detection of small molecules in living cells using genetically encoded FRET sensors has revolutionized our understanding of signaling pathways at the sub-cellular level. However, engineering fluorescent proteins and specific binding domains to create
Florencia Klein +7 more
doaj +1 more source
On the role of cyclic nucleotides in the transmitter choice made by cultured sympathetic neurons [PDF]
, 1981 Previous investigations have established that electrical activity or chronic depolarization influences the development of neonatal rat sympathetic neurons in dissociated cell culture.
Patterson, Paul H., Walicke, Patricia A.
core +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis [PDF]
, 2017 Background: Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/ cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life.
Biagioni, Stefano +5 more
core +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Genetically-encoded tools for cAMP probing and modulation in living systems.
Frontiers in Pharmacology, 2015 Intracellular 3'-5'-cyclic adenosine monophosphate (cAMP) is one of the principal second messengers downstream of a manifold of signal transduction pathways, including the ones triggered by G protein-coupled receptors.
Valeriy M Paramonov +3 more
doaj +1 more source
Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
doaj +1 more source
Regulation of the G2/M Transition in Rodent Oocytes [PDF]
, 2010 Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core +2 more sources
International Journal of Molecular Sciences, 2016 Cyclic nucleotide phosphodiesterases (PDEs) are the only enzymes that degrade the cyclic nucleotides cAMP and cGMP, and play a key role in modulating the amplitude and duration of the signal delivered by these two key intracellular second messengers ...
Marcella Brescia, M. Zaccolo
semanticscholar +1 more source
Cyclic nucleotides and amphibian development
Experimental Cell Research, 1975 Summary Addition of 3′, 5′-cyclic AMP (cAMP), N 6 , O 2 dibutyryl cyclic AMP (db-cAMP) and 3′,5′-cyclic GMP (cGMP) to fertilized amphibian eggs ( Ambystoma mexicanum, Xenopus laevis ) exerted little effect on development. Theophylline, at a high concentration (10 mM), produced strong developmental abnormalities; it had no effect at lower ...
Pays Deschutter, Annette +3 more
openaire +4 more sources