Results 31 to 40 of about 7,111 (103)

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Sodium Butyrate Attenuates Sevoflurane‐Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Repeated exposure to sevoflurane in neonatal mice leads to impaired myelin development and neurobehavioral dysfunction, a process closely associated with reduced butyrate levels in vivo. Sodium butyrate supplementation effectively ameliorates these sevoflurane‐induced abnormalities by downregulating HDAC3 and HDAC8 expression, enhancing H3K9ac levels ...
Chang Liu, Xinyao Bai, Xinyue Liu, Jinjie Li, Ruizhu Liu, Jinlan Jiang, Guoqing Zhao   +6 more
wiley   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 2128-2144, July 2026.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate

Molecular Microbiology, Volume 126, Issue 1, Page 15-23, July 2026.
The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki, Jessica L. Will, Jorge C. Escalante‐Semerena   +2 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, Volume 126, Issue 1, Page 98-110, July 2026.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Redox Imbalance and NOS-Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study. [PDF]

J Cell Mol Med
de Oliveira MG, Antunes E, Passos GR, Brito LGO, D'Ancona CAL, Monica FZ.   +5 more
europepmc   +1 more source

Phosphodiesterases Regulate <i>C. elegans</i> Bitter Taste Avoidance. [PDF]

MicroPubl Biol
Sojka SE, Hammond FM, Ferkey DM.
europepmc   +1 more source

Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance. [PDF]

ACS Omega
Wu Z, Ren H, Guo F.
europepmc   +1 more source

The Molecular Mechanism of PDE1 Regulation. [PDF]

Cells
Nielsen J, Langgård M, Tengberg JF, Kehler J.   +3 more
europepmc   +1 more source