AMPc i neuroinflamació: Identificació de proteïnes implicades en la regulació dels nivells d’AMPc en l’encefalomielitis autoimmune experimental [PDF]
, 2011 L'AMPc té un paper clau com a missatger intracel.lular regulant la transmissió dels senyals extracel•lulars en diferents teixits i controlant múltiples processos cel lulars.
Sanabra Palau, Cristina
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Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J. +2 more
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The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations [PDF]
, 2010 Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite ...
Terrin, A. +35 more
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The role of cGMP signalling in regulating life cycle progression of Plasmodium. [PDF]
, 2012 The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont ...
Baker, David A +2 more
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Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) in GtoPdb v.2021.3 [PDF]
, 2021 3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen
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Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) in GtoPdb v.2023.1 [PDF]
, 2023 3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen, Chen Yan
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Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis
Angewandte Chemie, EarlyView.The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood +6 more
wiley +2 more sources
The Role of Cyclic Nucleotide Phosphodiesterases [PDF]
, 2017 A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common signaling pathway.
Vandecasteele, Grégoire +6 more
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Multiple Isozymes of Cyclic Nucleotide Phosphodiesterases in the Rat [PDF]
, 1990 Cyclic nucleotide phosphodiesterases catalyse the hydrolysis of 3'5'-cyclic nucleotides, such as cyclic AMP and cyclic GMP, to produce 5'-derivatives.
Lavan, Brian Edward
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Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina +5 more
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