Results 1 to 10 of about 18,037,673 (136)

Cyclic Nucleotide Phosphodiesterase Families as Targets to Treat Pulmonary Arterial Hypertension: Beyond PDE5 Inhibitors? [PDF]

Cells
Pulmonary arterial hypertension (PAH) is a fatal disease with no cure. Until recently, most specific therapies for PAH had aimed at enhancing cyclic nucleotide (cAMP and cGMP) pathways, taking advantage of the vasorelaxant and antiproliferative ...
Liting Wang, Rodolphe Fischmeister, Boris Manoury   +2 more
doaj   +2 more sources

Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise [PDF]

Circulation, 2000
Background—Nitric oxide (NO) causes vasodilation by stimulation of guanylate cyclase in vascular smooth muscle to produce cGMP. The resultant vasodilator effect is regulated by a family of cGMP phosphodiesterases (PDEs). Sildenafil, a selective inhibitor of PDE5 used for treatment of erectile dysfunction, has been found to cause relaxation of isolated ...
J H, Traverse, Y J, Chen, R, Du, R J, Bache   +3 more
openaire   +2 more sources

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System

Journal of Cardiovascular Development and Disease, 2018
A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are essential enzymes in the cyclic adenosine 3’-5’ monophosphate (cAMP) signaling cascade.
Maria Ercu, Enno Klussmann
doaj   +1 more source

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management

Cells
Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential.
Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos   +4 more
doaj   +1 more source

The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence. [PDF]

Biochem J
Chi H, McMahon SA, Graham S, White MF.
europepmc   +2 more sources

Cyclic di-AMP signaling and regulation in <i>Staphylococcus aureus</i>. [PDF]

mSphere
Lee S, Kim J-H, Yun T, Lee W.
europepmc   +1 more source

Selective phosphodiesterase 4B inhibition in fibrotic lung disease: a scoping review of vascular-immune mechanisms and extrapulmonary implications. [PDF]

Eur Respir Rev
Perrotta F, Mariniello DF, Pagliaro R, Bianco A.   +3 more
europepmc   +1 more source

STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition. [PDF]

iScience
Bekere I, Hubarzhevska Y, Egender SV, Quoika PK, Öllinger R, Schrimpf MR, Rad R, Zacharias M, de Oliveira Mann CC.   +8 more
europepmc   +1 more source