Results 131 to 140 of about 825,768 (324)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Large-scale S-box design and analysis of SPS structure

open access: yesTongxin xuebao, 2023
A class of optimal linear transformation P over a finite field ( F 2 m ) 4 was constructed based on cyclic shift and XOR operation.Using the idea of inverse proof of input-output relation of ...
Lan ZHANG, Liangsheng HE, Bin YU
doaj   +2 more sources

On Volumes of Permutation Polytopes

open access: yes, 2011
This paper focuses on determining the volumes of permutation polytopes associated to cyclic groups, dihedral groups, groups of automorphisms of tree graphs, and Frobenius groups. We do this through the use of triangulations and the calculation of Ehrhart
Burggraf, Katherine   +2 more
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Periodic Ordered Permutation Groups and Cyclic Orderings

open access: yesJournal of Combinatorial Theory, Series B, 1995
It is shown that periodic ordered permutation groups satisfying certain extra conditions are very nearly simple. This is applied to several natural examples, such as the following. (i) If \(z\) denotes the map \(x \mapsto x + 1\) on \(\mathbb{R}\), and \(\text{Diff}(\mathbb{R})\) is the group of diffeomorphisms of \(\mathbb{R}\), then \(C_{\text{Diff}(\
Michèle Giraudet   +2 more
openaire   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

κ-Lookback random-based text encryption technique

open access: yesJournal of King Saud University: Computer and Information Sciences, 2019
Although many encryption methods are available, there is always an ongoing need for more to resist the adversaries’ ever-growing analytical skills and techniques. We propose in this paper an innovative method for text encryption.
Muhammed J. Al-Muhammed, Raed Abu Zitar
doaj   +1 more source

Home - About - Disclaimer - Privacy