Results 131 to 140 of about 227,971 (307)

Low cycle fatigue tests of reinforced concrete columns and joints built with ribbed reinforcement and plain stirrups

, 2012
The majority of existing reinforced concrete (RC) buildings were built prior to the introduction of seismic codes. As observed in various recent earthquakes, due to their lack of structural capacity and ductility such structures are very vulnerable and
Varum, H., Rossetto, T., Borg, R. C.
core  

Effect of initial static shear stress and cyclic loading direction on liquefaction characteristics of saturated dense sand

Yantu gongcheng xuebao
Soil elements of slope are subjected to both initial shear stress and cyclic stress during seismic loading, and the directions of initial shear stress and cyclic stress are often different.
ZHANG Yingbin, QIN Yiqiao , ZHANG Shihao , WEI Jiangtao, XIONG Yixiang , LIU Yonghang   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of sodium hypochlorite on the cyclic fatigue resistance: A scanning electron microscopy evaluation

, 2019
The main purpose of this study was to compare the cyclic fatigue resistances of the three different nickel-titanium files in 2.5% sodium hypochlorite solution and distilled water at physiologic intracanal temperature (35°C).
İhsan F. Ertuğrul, Ertuğrul, İhsan F.   +1 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Out-of-plane in situ cyclic testing of unreinforced stone masonry walls with distributed loads

, 2012
The present paper reports an in situ experimental test campaign carried out on existing buildings, in order to investigate the seismic behaviour of traditional masonry walls subject to out-of-plane loads.
Costa, A., Ferreira, T., Costa, A. A., Varum, H., Arêde, A., Garcia, F.   +5 more
core  

Correlation between cyclic resistance and shear-wave velocity for providence silts

, 2008
As an alternative to a field-based liquefaction resistance approach, cyclic triaxial tests with bender elements were used to develop a new correlation between cyclic resistance ratio (CRR) and overburden stress-corrected shear-wave velocity (VS1) for two
Wang, Jian Hua, Baxter, Christopher D.P., Bradshaw, Aaron S., Green, Russell A.   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source