Results 111 to 120 of about 227,971 (307)
Effects of principal stress rotation and drainage on the resilient stiffness of railway foundations
, 2013 Railway foundations play an integral role in controlling the stability of the overlying track structure and the maintenance of the overall track geometry.
Mamou, A.
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Liquefaction resistance of MICP-treated calcareous sand with different particle size and gradation
BiogeotechnicsCalcareous sand is a type of marine soil with the poor engineering performance and a high potential of liquefaction under seismic or wave action. To address this issue, microbially induced calcium carbonate precipitation (MICP), an eco-friendly bio ...
Yi Shan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Evaluation of the Effect of Cyclic Preloading on Cyclic Fatigue Resistance in Rotary File System
, 2022 AIM OF THE STUDY: The aim of this study is to evaluate and compare the effect of cyclic preloading on cyclic fatigue resistance in two rotary file systems. METHODOLOGY: Rotary files – One Shape and KOMET F360 were used for instrumentation in simulated
Poorani, D
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Undrained Cyclic Shear Resistance of Low Plastic Silts
, 2020 A magnitude 9 Cascadia Subduction Zone earthquake is expected to trigger widespread liquefaction in loose material in Oregon. The geotechnical engineering studies have determined that the Willamette Silts may be susceptible to liquefaction or cyclic ...
Almoumen, Rawan
core +1 more source
Saudi Endodontic JournalIntroduction: Nickel–titanium (NiTi) rotary files are widely used in endodontics. However, they have some drawbacks, such as file breakage due to torsional or cyclic fatigue.
Badi Alotaibi +4 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Investigation of the role of LRP in multidrug resistance [PDF]
, 1998 There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
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