Results 41 to 50 of about 227,971 (307)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Cyclic AMP and Fluconazole Resistance in Saccharomyces cerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae . We show that cAMP is required for resistance to fluconazole in S. cerevisiae . In addition, activation of Ras2 , a regulator of cAMP generation, results in some ...
D P, Kontoyiannis, S, Rupp
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Differences in Cyclic Fatigue Resistance at Apical and Coronal Levels of Reciproc and WaveOne New Files

, 2012
Introduction: Recent improvements in alloys, kinematics, and concepts have been combined to increase the cyclic fatigue resistance of nickel-titanium (NiTi) instruments.
Pérez-Higueras Sánchez-Escalonilla, Juan, Arias Paniagua, Ana María, Macorra García, José Carlos De La   +2 more
core   +1 more source

Low cycle fatigue life improvement of AISI 304 by initial and intermittent wire brush hammering [PDF]

, 2013
The effects of hammering by wire brush as a method of improving low cycle fatigue life of highly ductile austenitic stainless steel AISI 304 have been investigated through an experimental study combining imposed strain fatigue tests and assessment of ...
KHLIFI, Ammar, SIDHOM, Habib, MAKHLOUF, Kamel, SIDHOM, Naziha, BRAHAM, Chedly   +4 more
core   +1 more source

On the influence of cyclic preloadings on the liquefaction resistance of sands: A numerical study

, 2023
Soil deposits may be subjected to preloading episodes due to different factors such as previous earthquakes, excavations, refilling, compaction, construction of overlying structures, storms under onshore/offshore conditions, among many others. It is well-
D. Mašín, J. Duque, Mašín, D., Tafili, M., Duque, J., M. Tafili   +5 more
core   +1 more source

Effect of Temperatures on Cyclic Fatigue Resistance of 3 Different Ni-Ti Alloy Files

International Dental Journal, 2023
: Objective: The aim of this study was to investigate and compare the effect of temperature on the cyclic fatigue resistance of conventional (ProTaper Universal [PTU]), Gold-Wire (ProTaper Gold [PTG]), and Fire-Wire (EdgeTaper Platinum [ETP]) nickel ...
Sirawut Hiran-us, Sarita Morakul
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protozoan-induced regulation of cyclic lipopeptide biosynthesis Is an effective predation defense mechanism for Pseudomonas fluorescens [PDF]

, 2009
Environmental bacteria are exposed to a myriad of biotic interactions that influence their function and survival. The grazing activity of protozoan predators significantly impacts the dynamics, diversification, and evolution of bacterial communities in ...
de Bruijn, Irene, Mazzola, M., Mazzola, Mark, Bruijn, I., de, Cohen, Michael F, Cohen, M.F., Raaijmakers, Jos M, Raaijmakers, J.M., de Bruijn, I.   +8 more
core   +1 more source